Sedative effect of vapor inhalation of essential oil from Heracleum afghanicum Kitamura seeds

被引：10

作者：

Karimi, Abdul Ghani ^{[1
,2
]}

Ito, Michiho ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Pharmacognosy, Sakyo Ku, Kyoto, Japan

[2] Kabul Univ, Fac Pharm, Dept Pharmacognosy, Jamal Mina, Kabul, Afghanistan

来源：

JOURNAL OF ESSENTIAL OIL RESEARCH | 2012年 / 24卷 / 06期

关键词：

Heracleum afghanicum; Apiaceae; essential oil composition; vapor inhalation; sedative effect; aliphatic esters; hexyl butyrate; octyl acetate; ANTICONVULSANT ACTIVITY; IDENTIFICATION; EXTRACT;

D O I：

10.1080/10412905.2012.728085

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Heracleum afghanicum (Apiaceae) is a perennial plant indigenous to Afghanistan. Phytochemical and pharmacological analyses of H. afghanicum seeds essential oil were carried out to investigate its possible sedative effects on mice spontaneous locomotor activity. The essential oil was analyzed by gas chromatography (GC) and GC/mass spectrom-etry (GC/MS), and thirty-three constituents were identified. Hexyl butyrate (34.3%) and octyl acetate (21.1%) were found as its principal constituents. The sedative effect of H. afghanicum essential oil was confirmed using an open field test with ddY mice. The essential oil significantly decreased the locomotor activity of mice, suggesting its sedative effect. Hexyl butyrate and octyl acetate were found to be responsible for the sedative activity of H. afghanicum seeds essential oil.

引用

页码：571 / 577

页数：7

共 18 条

[1] Retention Indices for Most Frequently Reported Essential Oil Compounds in GC [J].

Babushok, Valeri I. ;

Zenkevich, Igor G. .

CHROMATOGRAPHIA, 2009, 69 (3-4) :257-269

[2]

Evans W.C., 2002, Trease and Evans Pharmacognosy

[3]

Golberg L., 1974, FOOD COSMETIC TOXICO, V12, P815

[4] Anti-inflammatory and analgesic properties of Heracleum persicum essential oil and hydroalcoholic extract in animal models [J].

Hajhashemi, Valiollah ;

Sajjadi, Seyed Ebrahim ;

Heshmati, Mojtaba .

JOURNAL OF ETHNOPHARMACOLOGY, 2009, 124 (03) :475-480

[5]

Jocelyn G., 1997, J CHEM ECOL, V23, P1743

[6] Chemical composition of leaf and fruit oils of Heracleum candolleanum [J].

John, Anil J. ;

Karunakaran, Vrujesh P. ;

George, Varughese ;

Sethuraman, Mathur G. .

JOURNAL OF ESSENTIAL OIL RESEARCH, 2007, 19 (04) :358-359

[7]

Kuljanabhagavad T, 2010, J HEALTH RES, V24, P55

[8]

Mojab F., 2003, Iranian Journal of Pharmaceutical Research, V2, P245

[9] COMPOSITION OF THE ESSENTIAL OIL FROM HERACLEUM-DISSECTUM [J].

PAPAGEORGIOU, VP ;

OCHIR, G ;

MOTL, O ;

ARGYRAIDOU, N ;

DUNKEL, H .

JOURNAL OF NATURAL PRODUCTS, 1985, 48 (05) :851-853

[10] Anticonvulsant activity of Heracleum persicum seed [J].

Sayyah, M ;

Moaied, S ;

Kamalinejad, M .

JOURNAL OF ETHNOPHARMACOLOGY, 2005, 98 (1-2) :209-211

← 1 2 →