The cytoskeleton in cell-autonomous immunity: structural determinants of host defence

被引：127
|
作者：
Mostowy, Serge [1 ]
Shenoy, Avinash R. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, CMBI, Med Res Council, London SW7 2AZ, England
来源：
NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 09期
基金：
英国惠康基金;
关键词：
NONCANONICAL INFLAMMASOME ACTIVATION; ACTIN-BASED MOTILITY; RHO GTPASES; INNATE IMMUNITY; AUTOINFLAMMATORY DISEASE; PYRIN INFLAMMASOME; AIM2; INFLAMMASOME; AUTOPHAGY PATHWAY; FC-RECEPTOR; RIG-I;
D O I：
10.1038/nri3877
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Host cells use antimicrobial proteins, pathogen-restrictive compartmentalization and cell death in their defence against intracellular pathogens. Recent work has revealed that four components of the cytoskeleton-actin, microtubules, intermediate filaments and septins, which are well known for their roles in cell division, shape and movement have important functions in innate immunity and cellular self-defence. Investigations using cellular and animal models have shown that these cytoskeletal proteins are crucial for sensing bacteria and for mobilizing effector mechanisms to eliminate them. In this Review, we highlight the emerging roles of the cytoskeleton as a structural determinant of cell-autonomous host defence.
引用
收藏
页码：559 / 573
页数：15
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