Metabonomics Study of Essential Hypertension and Its Chinese Medicine Subtypes by Using Gas Chromatography-Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy

被引：20
作者：
Li, Yunlun [1 ]
Nie, Lei [2 ]
Jiang, Haiqiang [3 ]
Lin, Jiamao [3 ]
Zhou, Honglei [3 ]
Xie, Jun [3 ]
Qu, Zhengjun [3 ]
Qi, Dongmei [3 ]
Zhang, Yunhui [1 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Cardiol, Jinan 250011, Peoples R China
[2] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan 250355, Peoples R China
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2013年 / 2013卷
基金：
中国国家自然科学基金;
关键词：
LIQUID-CHROMATOGRAPHY; INSULIN-RESISTANCE; SYSTEMS BIOLOGY; RAT MODEL; PERFORMANCE; PLASMA;
D O I：
10.1155/2013/625906
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
A metabonomic study was performed to investigate the metabolic mechanism of essential hypertension and its Chinese medicine subtypes, including "Yin-deficiency and Yang-hyperactivity syndrome" (YDYHS) and "Yin-Yang deficiency syndrome" (YYDS). Plasma samples from 22 healthy volunteers, 31 hypertensive patients with YDYHS, and 29 hypertensive patients with YYDS were analyzed by H-1-NMR spectroscopy and gas chromatography coupled with mass spectrometry (GC-MS). The three groups were distinctly classified by principal components analysis (PCA) and partial least squares discriminant analysis (PLS-DA). According to identified biomarkers and their related pathways, abnormal glucose metabolism might be the main common pathway from YDYHS to YYDS, and sympathetic nervous system activation would play an important role in the pathogenesis of YDYHS, while a low metabolic rate usually occurred in YYDS.
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页数：9
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