Neuroprotective effects of afobazol in experimental cerebral hemorrhage

被引：18

作者：

Galaeva, IP ^{[1
]}

Garibova, TL ^{[1
]}

Voronina, TA ^{[1
]}

Seredenin, SB ^{[1
]}

机构：

[1] Russian Acad Med Sci, VV Zakusov State Res Inst Pharmacol, Moscow 109801, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2005年 / 140卷 / 05期

关键词：

afobazol; cerebral hemorrhage; neural deficiency; learning; memory;

D O I：

10.1007/s10517-006-0017-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The study of novel selective anxiolytic afobazol on rats with experimental intracerebral post-traumatic hematoma (cerebral hemorrhage) demonstrated its efficiency in a dose of 5 mg/kg applied by a single or repeated administration for 2 weeks. The preparation significantly decreased the incidence of neurological disturbances in most rats (pareses, paralyses, convulsive movements, lateral posture). The therapeutic course of afobazol improved survival rate. Afobazol improved learning and memory in rats with cerebral hemorrhage in the conditioned passive avoidance test and positively affected motor activity in the open field test, which was documented by significant increase in total motor activity indices. The effects of afobazol were more pronounced after course treatment.

引用

页码：535 / 537

页数：3

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