Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation

被引：18
作者：
Grabellus, F
Sheu, SY
Schmidt, B
Flasshove, M
Kuhnen, C
Ruchholtz, S
Taeger, G
Schmid, KW
机构：
[1] Univ Duisburg Essen, Univ Hosp Essen, Inst Pathol, D-45122 Essen, Germany
[2] Univ Hosp Essen, Dept Trauma Surg, Essen, Germany
[3] Univ Hosp Essen, Dept Internal Med Canc Res, Essen, Germany
[4] Univ Hosp Bergmannsheil, Inst Pathol, Bochum, Germany
来源：
VIRCHOWS ARCHIV | 2006年 / 448卷 / 01期
关键词：
sarcomas; soft tissue;
D O I：
10.1007/s00428-005-0094-0
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Leiomyosarcomas (LM) of the soft tissue comprise approximately 5-10% of all soft tissue sarcomas. Besides the classic LM, several distinctly uncommon features of the cellular and growth patterns of LM have been described. The term "dedifferentiated LM" has rarely been used in the literature to describe soft tissue LM containing areas of undifferentiated, pleomorphic appearance or detectable heterologous differentiation. We report on a case of high-grade LM with almost entire transition to an osteosarcoma, which was classified as recurrent high-grade LM with heterologous osteosarcomatous differentiation. The identification of areas with osteosarcomatous dedifferentiation in soft tissue sarcomas can be of clinical importance because of a possible change in oncologic treatment strategies.
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收藏
页码：85 / 89
页数：5
相关论文
共 23 条
[1]   Extraosseous osteosarcoma: Response to treatment and long-term outcome [J].
Ahmad, SA ;
Patel, SR ;
Ballo, MT ;
Baker, TP ;
Yasko, AW ;
Wang, XM ;
Feig, BW ;
Hunt, KK ;
Lin, PP ;
Weber, KL ;
Chen, LL ;
Zagars, GK ;
Pollock, RE ;
Benjamin, RS ;
Pisters, PWT .
JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (02) :521-527
[2]   Osteoclast-like giant cells in leiomyomatous tumors of the uterus - A case report and review of the literature [J].
Aru, A ;
Norup, P ;
Bjerregaard, B ;
Andreasson, B ;
Horn, T .
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2001, 80 (04) :371-374
[3]  
Brady MS, 1996, CANCER, V77, P467, DOI 10.1002/(SICI)1097-0142(19960201)77:3<467::AID-CNCR7>3.0.CO
[4]  
2-H
[5]   Osteosarcoma arising in a metastatic leiomyosarcoma [J].
Feeley, C ;
Gallagher, P ;
Lang, D .
HISTOPATHOLOGY, 2005, 46 (01) :111-113
[6]   HISTOLOGICAL FEATURES OF LOCAL RECURRENCE IN SOFT-TISSUE SARCOMAS [J].
FLETCHER, CDM .
PATHOLOGE, 1994, 15 (04) :196-200
[7]  
FLETCHER CDM, 2002, WHO CLASSIFICATION T
[8]  
Gazziola C, 2003, INT J ONCOL, V23, P343
[9]   Extraskeletal osteosarcoma has a favourable prognosis when treated like conventional osteosarcoma [J].
Goldstein-Jackson, SY ;
Gosheger, G ;
Delling, G ;
Berdel, WE ;
Exner, GU ;
Jundt, G ;
Machatschek, JN ;
Zoubek, A ;
Jürgens, H ;
Bielack, SS .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2005, 131 (08) :520-526
[10]   RETRODIFFERENTIATION AND CELL-DEATH [J].
HASS, R .
CRITICAL REVIEWS IN ONCOGENESIS, 1994, 5 (04) :359-371
123