Listeria monocytogenes sequence type 1 is predominant in ruminant rhombencephalitis

被引：81

作者：

Dreyer, Margaux ^{[1
,2
]}

Aguilar-Bultet, Lisandra ^{[2
,3
]}

Rupp, Sebastian ^{[1
,2
]}

Guldimann, Claudia ^{[1
,2
,14
]}

Stephan, Roger ^{[4
]}

Schock, Alexandra ^{[5
]}

Otter, Arthur ^{[6
]}

Schupbach, Gertraud ^{[7
]}

Brisse, Sylvain ^{[8
]}

Lecuit, Marc ^{[9
,10
,11
,12
,13
]}

Frey, Joachim ^{[3
]}

Oevermann, Anna ^{[1
]}

机构：

[1] Univ Bern, Vetsuisse Fac, Dept Clin Res & Vet Publ Hlth, Div Neurol Sci, CH-3012 Bern, Switzerland

[2] Univ Bern, Theodor Kocher Inst, Grad Sch Cellular & Biomed Sci, CH-3012 Bern, Switzerland

[3] Univ Bern, Dept Infect Dis & Pathobiol, Inst Vet Bacteriol, CH-3012 Bern, Switzerland

[4] Univ Zurich, Inst Food Safety & Hyg, CH-8006 Zurich, Switzerland

[5] AHVLA Lasswade, Dept Pathol, Pentlands Sci Pk, Penicuik, Midlothian, Scotland

[6] AHVLA Shrewsbury Kendal Rd, Shrewsbury, Shrops, England

[7] Univ Bern, Vet Publ Hlth Inst, CH-3012 Bern, Switzerland

[8] Inst Pasteur, Microbial Evolutionary Genom, Paris, France

[9] Inst Pasteur, Biol Infect Unit, Paris, France

[10] INSERM, U1117, Paris, France

[11] Inst Pasteur, French Natl Reference Ctr, Paris, France

[12] Inst Pasteur, WHO Collaborating Ctr Listeria, Paris, France

[13] Paris Descartes Univ, Inst Imagine, Div Infect Dis & Trop Med, Necker Enfants Malad Univ Hosp,Sorbonee Paris Cit, Paris, France

[14] Univ Zurich, Inst Food Safety & Hyg, CH-8006 Zurich, Switzerland

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

瑞士国家科学基金会;

关键词：

TANDEM-REPEAT ANALYSIS; CENTRAL-NERVOUS-SYSTEM; GENETIC-CHARACTERIZATION; NEUROPATHOLOGICAL SURVEY; CLINICAL-MANIFESTATIONS; INFECTION; DISTINCT; SHEEP; FOODS; EPIDEMIOLOGY;

D O I：

10.1038/srep36419

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Listeria (L.) monocytogenes is an opportunistic pathogen causing life-threatening infections in diverse mammalian species including humans and ruminants. As little is known on the link between strains and clinicopathological phenotypes, we studied potential strain-associated virulence and organ tropism in L. monocytogenes isolates from well-defined ruminant cases of clinical infections and the farm environment. The phylogeny of isolates and their virulence-associated genes were analyzed by multilocus sequence typing (MLST) and sequence analysis of virulence-associated genes. Additionally, a panel of representative isolates was subjected to in vitro infection assays. Our data suggest the environmental exposure of ruminants to a broad range of strains and yet the strong association of sequence type (ST) 1 from clonal complex (CC) 1 with rhombencephalitis, suggesting increased neurotropism of ST1 in ruminants, which is possibly related to its hypervirulence. This study emphasizes the importance of considering clonal background of L. monocytogenes isolates in surveillance, epidemiological investigation and disease control.

引用

页数：11

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