Ertapenem use and antimicrobial resistance to group 2 carbapenems in Gram-negative infections: a systematic review

被引:1
|
作者
Falagas, Matthew E. [1 ,2 ,3 ]
Tansarli, Giannoula S. [1 ]
Kapaskelis, Anastasios [1 ,2 ]
Vardakas, Konstantinos Z. [1 ,2 ]
机构
[1] Alfa Inst Biomed Sci, Athens 15123, Greece
[2] Mitera Hosp, Hygeia Grp, Dept Internal Med Infect Dis, Athens, Greece
[3] Tufts Univ, Sch Med, Boston, MA 02111 USA
关键词
Enterobacteriaceae; ertapenem; Gram-negative; group; 2; carbapenem; Pseudomonas; resistance; PSEUDOMONAS-AERUGINOSA; RISK-FACTORS; FLUOROQUINOLONE USE; HOSPITAL FORMULARY; ESCHERICHIA-COLI; SUSCEPTIBILITY; STEWARDSHIP; ENTEROBACTERIACEAE; REDUCTION; IMIPENEM;
D O I
10.1586/ERI.12.149
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The authors sought to evaluate the impact of ertapenem use on the resistance of Gram-negative bacteria (in general and in specific species) to group 2 carbapenems. PubMed and Scopus databases were systematically searched. Eight studies were included; all reported on Pseudomonas aeruginosa and four reported on Enterobacteriaceae. Five studies did not show any difference in group 2 carbapenem resistance for P. aeruginosa, while three reported a significant decline after ertapenem introduction. Three studies did not show any difference in group 2 carbapenem resistance between the compared periods for Enterobacteriaceae and one study did not present a statistical analysis. In conclusion, the currently available data suggest that ertapenem use does not affect the resistance of Gram-negative bacteria to group 2 carbapenems.
引用
收藏
页码:69 / 78
页数:10
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