Neuromyelitis optica: Aquaporin-4 based pathogenesis mechanisms and new therapies

被引:90
作者
Ratelade, Julien
Verkman, A. S. [1 ]
机构
[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
关键词
NMO; Devic's disease; Aquaporin-4; Astrocyte; Complement; Autoimmunity; INSENSITIVE WATER CHANNEL; NMO-IGG BINDING; ORTHOGONAL ARRAYS; MICE LACKING; IMMUNOGLOBULIN-G; PLASMA-MEMBRANES; MULTIPLE-SCLEROSIS; BRAIN EDEMA; MOUSE-BRAIN; SPINAL-CORD;
D O I
10.1016/j.biocel.2012.06.013
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neuromyelitis optica (NMO) is an autoimmune 'aquaporinopathy' of the central nervous system that causes inflammatory demyelinating lesions primarily in spinal cord and optic nerve, leading to paralysis and blindness. NMO lesions show loss of aquaporin-4 (AQP4), GFAP and myelin, infiltration of granulocytes and macrophages, and perivascular deposition of activated complement. Most patients with NMO are seropositive for immunoglobulin autoantibodies (AQP4-IgG) against AQP4, the principal water channel of astrocytes. There is strong evidence that AQP4-IgG is pathogenic in NMO, probably by a mechanism involving complement-dependent astrocyte cytotoxicity, causing leukocyte infiltration, cytokine release and blood-brain barrier disruption, which leads to oligodendrocyte death, myelin loss and neuron death. Here, we review the evidence for this and alternative proposed NMO pathogenesis mechanisms, such as AQP4-IgG-induced internalization of AQP4 and glutamate transporters, complement-independent cell-mediated cytotoxicity, and AQP4-IgG inhibition of AQP4 water transport function. Based on the initiating pathogenic role of AQP4-IgG binding to astrocyte AQP4 in NMO, selective blocker therapies are under development in which AQP4-targeted monoclonal antibodies or small molecules block binding of AQP4-IgG to astrocytes and consequent downstream pathology. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1519 / 1530
页数:12
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