The role of melatonin in colorectal cancer treatment: a comprehensive review

被引：22

作者：

Kvietkauskas, Mindaugas ^{[2
,3
]}

Zitkute, Viktorija ^{[2
,3
]}

Leber, Bettina ^{[2
]}

Strupas, Kestutis ^{[3
]}

Stiegler, Philipp ^{[1
]}

Schemmer, Peter ^{[2
]}

机构：

[1] Med Univ Graz, Dept Surg, Transplant Ctr Graz, Gen Visceral & Transplant Surg, Auenbruggerpl 29, A-8036 Graz, Austria

[2] Med Univ Graz, Dept Surg, Gen Visceral & Transplant Surg, Graz, Austria

[3] Vilnius Univ, Fac Med, Vilnius, Lithuania

来源：

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2020年 / 12卷

关键词：

anticancer drug combinations; colorectal cancer; melatonin; review; PINEAL HORMONE MELATONIN; LOW-DOSE INTERLEUKIN-2; GROWTH IN-VITRO; COLON CARCINOGENESIS; PROLIFERATIVE ACTIVITY; CELL-PROLIFERATION; GENE-EXPRESSION; POSSIBLE INVOLVEMENT; PROMOTES APOPTOSIS; SIGNALING PATHWAYS;

D O I：

10.1177/1758835920931714

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is one of the most common types of cancer worldwide, known as the second leading cause of cancer-related deaths annually. Currently, multimodal treatment strategies, including surgical resection, combined with chemotherapy and radiotherapy, have been used as conventional treatments in patients with CRC. However, clinical outcome of advanced stage disease remains relatively discouraging, due mainly to appearance of CRC chemoresistance, toxicity, and other detrimental side effects. New strategies to overcome these limitations are essential. During the last decades, melatonin (MLT) has been shown to be a potent antiproliferative, anti-metastatic agent with cytotoxic effects on different types of human malignancies, including CRC. Hence, this comprehensive review compiles the available experimental and clinical data analyzing the effects of MLT treatment in CRC patients and its underlying molecular mechanisms.

引用

页数：14

共 121 条

[1] Chemotherapy prior to Hepatic Resection for Colorectal Liver Metastases: Helpful until Harmful? [J].