Effect of the Intake of Resveratrol, Resveratrol Phosphate, and Catechin-Rich Grape Seed Extract on Markers of Oxidative Stress and Gene Expression in Adult Obese Subjects

被引：65

作者：

De Groote, Donat ^{[1
]}

Van Belleghem, Kristof ^{[2
]}

Deviere, Jacques ^{[3
]}

Van Brussel, Willy ^{[2
]}

Mukaneza, Anne ^{[1
]}

Amininejad, Leila ^{[3
]}

机构：

[1] PROBIOX SA, BE-4140 Sprimont, Belgium

[2] NV Ajinomoto Omnichem SA, Wetteren, Belgium

[3] Univ Libre Bruxelles, Erasme Hosp, Dept Gastroenterol Hepatopancreatol & Digest Onco, Brussels, Belgium

来源：

ANNALS OF NUTRITION AND METABOLISM | 2012年 / 61卷 / 01期

关键词：

Resveratrol; Catechin; Grape seed extract; Oxidative stress; Gene expression; Microarray; BREAST-CANCER CELLS; TRANS-RESVERATROL; POLYPHENOLIC ANTIOXIDANTS; SAFETY EVALUATION; ORAL TOXICITY; HUMAN-DISEASE; DNA-DAMAGE; RED WINE; QUERCETIN; RATS;

D O I：

10.1159/000338634

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The preventive effect of resveratrol (RES) on the development of human diseases has been verified by numerous epidemiological studies. Resveratrol triphosphate (RTP) is a stable derivative of RES in which phosphate groups protect the phenolic groups. Aims: This study compared the effect of RIP on biochemical and molecular markers of oxidative stress to equimolar doses (0.66 mmol) of RES and catechin-rich grape seed extract (CGSE) in a model of oxidative and metabolic stress associated with obesity in humans. Methods:Thirty-two obese subjects (BMI between 30 and 40) were enrolled. They all received 1 capsule of placebo/day for 28 days before being randomly devised into three arms receiving 1 capsule/day of RES, CGSE, or RIP during the following consecutive 28 days. Blood samples were collected at baseline, after the end of placebo intake, and after the end of the investigational product intake. Biochemical parameters of oxidative stress and blood expression of 200 redox-related genes were determined at each time point. Results: RTP and CGSE showed better antioxidant activities compared to RES and induced important modulations of gene expression. Conclusion: The results suggest that RIP and CGSE could contribute to a significant reduction of oxidative stress in obese subjects. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：15 / 24

页数：10

共 55 条

[1] Blueberry Phytochemicals Inhibit Growth and Metastatic Potential of MDA-MB-231 Breast Cancer Cells through Modulation of the Phosphatidylinositol 3-Kinase Pathway [J].