Levosimendan protects against ischemia - reperfusion injury in the human heart muscle. A pilot study

被引：0

作者：

Kunecki, Marcin ^{[1
]}

Oleksy, Tomasz ^{[1
]}

Nozynski, Jerzy ^{[2
]}

Podolec, Piotr ^{[3
]}

Biernat, Jolanta ^{[1
]}

Deja, Marek Andrzej ^{[4
]}

Golba, Krzysztof Stanislaw ^{[1
]}

Plazak, Wojciech ^{[3
]}

机构：

[1] Med Univ Silesia, Dept Electrocardiol & Heart Failure, Katowice, Poland

[2] Med Univ Silesia, Dept Histol & Embryol, Katowice, Poland

[3] Jagiellonian Univ, John Paul II Hosp, Dept Cardiac & Vasc Dis, Med Coll, Krakow, Poland

[4] Med Univ Silesia, Dept Cardiac Surg, Katowice, Poland

来源：

CURRENT ISSUES IN PHARMACY AND MEDICAL SCIENCES | 2022年 / 35卷 / 04期

关键词：

ischemia; reperfusion; levosimendan; morphology of MI; cardioprotection; CALCIUM SENSITIZER LEVOSIMENDAN; LOW CARDIAC-OUTPUT; PERIOPERATIVE USE; K-ATP; CHANNELS; FAILURE; FLOW;

D O I：

10.2478/cipms-2022-0038

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The consequences of myocardial infarction (MI) are an increasing problem worldwide. Despite spectacular progress in the invasive treatment of ischemic heart disease, the ability to limit the ischemia-reperfusion (I/R) injury remains largely unrealized. Recent studies have shown that stimulation of opioid receptors may confer a cardioprotective effect against I/R injury. Levosimendan, the inodilator, is indicated for the shortterm treatment of acutely decompensated heart failure. We tested the hypothesis that levosimendan may provide cardioprotection in the opioid-like mechanism in the human myocardium.

引用

页码：219 / 223

页数：5

共 21 条

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