5α-dihydrotestosterone abrogates sex bias in asthma like features in the mouse

被引：14

作者：

Cerqua, Ida ^{[1
]}

Terlizzi, Michela ^{[2
]}

Bilancia, Rossella ^{[1
]}

Riemma, Maria A. ^{[1
]}

Citi, Valentina ^{[3
]}

Martelli, Alma ^{[3
]}

Pace, Simona ^{[4
]}

Spaziano, Giuseppe ^{[5
]}

D'Agostino, Bruno ^{[5
]}

Werz, Oliver ^{[4
]}

Ialenti, Armando ^{[1
]}

Sorrentino, Rosalinda ^{[2
]}

Cirino, Giuseppe ^{[1
]}

Rossi, Antonietta ^{[1
]}

Roviezzo, Fiorentina ^{[1
]}

机构：

[1] Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy

[2] Univ Salerno, Dept Pharm DIFARMA, Via Giovanni Paolo II 132 Fisciano, I-84084 Salerno, Italy

[3] Univ Pisa, Dept Pharm, Via Bonanno 6, I-56100 Pisa, Italy

[4] Friedrich Schiller Univ, Inst Pharm, Dept Pharmaceut Med Chem, Philosophenweg 14, D-07743 Jena, Germany

[5] Univ Campania Luigi Vanvitelli, Sch Med, Pharmacol Sect, Dept Expt Med L Donatelli, Via Costantinopoli 16, I-80131 Naples, Italy

来源：

PHARMACOLOGICAL RESEARCH | 2020年 / 158卷

关键词：

5; alpha-dihydrotestosterone; Airway hyperreactivity; Leukotrienes; Mast cells; Sensitization; Sex; LEUKOTRIENE BIOSYNTHESIS; GENDER-DIFFERENCES; MAST-CELL; TESTOSTERONE; INFLAMMATION; HYPERRESPONSIVENESS; ANDROGENS; HEALTH;

D O I：

10.1016/j.phrs.2020.104905

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Androgen levels inversely correlate with the incidence, susceptibility and severity of asthma. However, whether male sex hormones such as 5 alpha-dihydrotestosterone (DHT) have beneficial effects on asthma symptoms and/or could affect asthma susceptibility have not been investigated. DHT administration to female mice, during the sensitization phase, abrogates the sex bias in bronchial hyperreactivity. This effect correlates with inhibition of leukotriene biosynthesis in the lung. DHT significantly inhibits also other asthma-like features such as airway hyperplasia and mucus production in sensitized female mice. Conversely, DHT does not affect plasma IgE levels as well as CD3(+)CD4(+) IL-4(+) cell and IgE(+)c-Kit(+) cell infiltration within the lung but prevents pulmonary mast cell activation. The in vitro study on RBL-2H3 cells confirms that DHT inhibits mast cell degranulation. In conclusion, our data demonstrate that immunomodulatory effects of DHT on mast cell activation prevent the translation of allergen sensitization into clinical manifestation of asthma.

引用

页数：10

共 39 条

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