Application of the Radical Polyene Cyclization Reaction in Natural Product Synthesis

被引：6

作者：

Yao Liangcai ^{[1
]}

Gui Jinghan ^{[2
]}

机构：

[1] Shanghai Normal Univ, Coll Chem & Mat Sci, Shanghai 200233, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, CAS Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 42卷 / 09期

基金：

中国国家自然科学基金;

关键词：

polycyclic skeleton; polyene epoxide; free radical; cascade cyclization; natural product synthesis; CATALYZED 5-EXO CYCLIZATIONS; STEREOCHEMICAL CONTROL; ENANTIOSELECTIVE SYNTHESIS; SPONGIAN DITERPENES; GAMMA-LACTONES; FORCE-FIELD; TANDEM; EPOXYNITRILES; BIOSYNTHESIS; INTERMEDIATE;

D O I：

10.6023/cjoc202204044

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polycyclic compounds, which exist widely in natural products, synthetic drugs, agrochemicals, fine chemicals, etc. have a wide range of biological activities. Therefore, efficient synthesis of polycyclic compounds is an important research direction in organic synthesis. In recent years, free radical cascade cyclization of polyenes has increasingly become a reliable and concise way to construct polycyclic skeletons. However, the research papers on free radical cascade cyclization, especially those initiated by the homolysis of epoxides, have not been summarized. Therefore, this paper mainly reviews the initiation methods of free radical polyene cascade cyclization and its application in the synthesis of polycyclic natural products, with an emphasis on the Ti(III)-mediated free radical cascade cyclization of polyene epoxides.

引用

页码：2703 / 2714

页数：12

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