Biosensors for breast cancer diagnosis: A review of bioreceptors, biotransducers and signal amplification strategies

被引：207

作者：

Mittal, Sunil ^{[1
]}

Kaur, Hardeep ^{[1
]}

Gautam, Nandini ^{[1
]}

Mantha, Anil K. ^{[2
]}

机构：

[1] Cent Univ Punjab, Ctr Environm Sci & Technol, Bathinda 151001, India

[2] Cent Univ Punjab, Ctr Anim Sci, Bathinda 151001, India

来源：

BIOSENSORS & BIOELECTRONICS | 2017年 / 88卷

关键词：

Breast cancer; Biomarkers; Nanomaterials; Redox mediators; Redox cycling; SURFACE-PLASMON RESONANCE; CIRCULATING TUMOR-CELLS; LABEL-FREE DETECTION; ULTRASENSITIVE ELECTROCHEMICAL DETECTION; HIGHLY SENSITIVE DETECTION; GROWTH-FACTOR RECEPTOR; CARBOHYDRATE ANTIGEN 15-3; DUPLEX-SPECIFIC NUCLEASE; ACOUSTIC-WAVE BIOSENSOR; GOLD NANOPARTICLES;

D O I：

10.1016/j.bios.2016.08.028

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Breast cancer is highly prevalent in females and accounts for second highest number of deaths, worldwide. Cumbersome, expensive and time consuming detection techniques presently available for detection of breast cancer potentiates the need for development of novel, specific and ultrasensitive devices. Biosensors are the promising and selective detection devices which hold immense potential as point of care (POC) tools. Present review comprehensively scrutinizes various breast cancer biosensors developed so far and their technical evaluation with respect to efficiency and potency of selected bioreceptors and biotransducers. Use of glycoproteins, DNA biomarkers, micro-RNA, circulatory tumor cells (CTC) and some potential biomarkers are introduced briefly. The review also discusses various strategies used in signal amplification such as nanomaterials, redox mediators, p19 protein, duplex specific nucleases (DSN) and redox cycling. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：217 / 231

页数：15

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