Curvature-driven membrane lipid and protein distribution

被引：46

作者：

Callan-Jones, Andrew ^{[1
,2
]}

Bassereau, Patricia ^{[3
,4
,5
]}

机构：

[1] CNRS, Lab Charles Coulomb, UMR 5207, F-34095 Montpellier, France

[2] Univ Montpellier 2, F-34095 Montpellier, France

[3] Inst Curie, Ctr Rech, F-75248 Paris 05, France

[4] CNRS, PhysicoChim Curie, UMR168, F-75248 Paris, France

[5] Univ Paris 06, F-75252 Paris, France

来源：

CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE | 2013年 / 17卷 / 04期

关键词：

Membrane curvature; Lipid sorting; Protein sorting; In vitro experiments; Spontaneous curvature; Bending rigidity; N-BAR proteins; Protein insertion; Amphipathic helices; Protein scaffold; ENDOPHILIN N-BAR; AMPHIPATHIC HELICES; TUBULAR MEMBRANES; STRUCTURAL BASIS; DOMAINS; MECHANISMS; GENERATION; BILAYERS; RAFTS; AMPHIPHYSIN;

D O I：

10.1016/j.cossms.2013.08.004

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Cellular transport requires that membranes have the ability to recruit specific lipids and proteins to particular positions and at specific times. Here, we review recent work showing that lipids and proteins can be redistributed by spatially varying membrane curvature, without necessarily the need for biochemical targeting signals. We present here an emerging understanding of the various mechanisms by which membrane curvature can sort lipids and proteins, providing the experimental methods in addition to the supporting theoretical concepts. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：143 / 150

页数：8

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