A Case of Steroid-Responsive, COVID-19 Immune Reconstitution Inflammatory Syndrome Following the Use of Granulocyte Colony-Stimulating Factor

被引：16

作者：

Mertens, Jonathan ^{[1
]}

Laghrib, Yassine ^{[1
]}

Kenyon, Chris ^{[2
,3
]}

机构：

[1] Univ Hosp Antwerp, Dept Internal Med, Antwerp, Belgium

[2] Inst Trop Med, Dept Clin Sci, HIV STI Unit, Antwerp, Belgium

[3] Univ Cape Town, Div Infect Dis & HIV Med, Anzio Rd, ZA-7700 Observatory, South Africa

来源：

OPEN FORUM INFECTIOUS DISEASES | 2020年 / 7卷 / 08期

关键词：

ARDS; COVID-19; granulocyte-colony stimulating factor; immune reconstitution inflammatory syndrome; IRIS; SARS-CoV-2; TUBERCULOSIS; TRIAL;

D O I：

10.1093/ofid/ofaa326

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We present a case report of a 54-year-old male with metastasized nasopharyngeal carcinoma presenting to the hospital with dyspnea, anorexia and fever. Examination revealed chemotherapy-induced pancytopenia. The patient tested positive for SARSCoV-2, but respiratory complications were mild. The patient was treated with granulocyte-colony stimulating factor (G-CSF) leading to amelioration of the neutropenia. However, severe acute respiratory distress syndrome (ARDS) occurred, prompting the diagnosis of immune reconstitution inflammatory syndrome (IRIS). GCSF is currently investigated as additional therapy in ARDS, but this case report emphasizes that risks and benefits must be carefully assessed. To our knowledge, this is the first case report of IRIS-induced ARDS in a COVID-19 patient.

引用

页数：3

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