Synthesis of novel imidazo[2,1-b][1,3,4]thiadiazoles appended to sydnone as anticancer agents

被引：25

作者：

Tegginamath, Gireesh ^{[1
]}

Kamble, Ravindra R. ^{[1
]}

Taj, Tasneem ^{[1
]}

Kattimani, Pramod P. ^{[1
]}

Meti, Gangadhar Y. ^{[1
]}

机构：

[1] Karnatak Univ, Dept Studies Chem, Dharwad 580003, Karnataka, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 09期

关键词：

Sydnone; Coumarin; Imidazo[2,1-b][1,3,4]thiadiazole; Anticancer; DNA cleavage; BIOLOGICAL EVALUATION; ANTIBACTERIAL; DERIVATIVES; ANTIFUNGAL; SERIES;

D O I：

10.1007/s00044-012-0441-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of 3-aryl-4{6'-(6''-substituted-coumarin-3''-yl) imidazo[2,1-b][1,3,4]thiadiazol-2'-yl}-sydnones 5h-5s were synthesized and screened for their anticancer and DNA cleavage activities and analyzed for pharmacological parameters such as toxicity, drug-likeliness, and drug score for oral bioavailability. In vitro toxicity assay was carried out by assessing the survival E. coli AB1157 (wild type) cultures. Some of the compounds have shown significant anticancer activities also.

引用

页码：4367 / 4375

页数：9

共 33 条

[1]

Amantea ML, 2011, ASIAN J PHARM HLTH, V1, P89

[2]

Andotra CS, 1997, J INDIAN CHEM SOC, V74, P125

[3] SYNTHESIS AND DIURETIC ACTIVITY OF IMIDAZO[2,1-B]THIAZOLE ACETOHYDRAZONES [J].

ANDREANI, A ;

RAMBALDI, M ;

MASCELLANI, G ;

RUGARLI, P .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1987, 22 (01) :19-22

[4]

ANDREANI A, 1986, EUR J MED CHEM, V21, P451

[5] 5-FORMYLIMIDAZO[2,1-B]THIAZOLES AND DERIVATIVES WITH HERBICIDAL ACTIVITY [J].

ANDREANI, A ;

RAMBALDI, M ;

LOCATELLI, A ;

ANDREANI, F .

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1991, 56 (11A) :2436-2447

[6]

Andreani A, 2000, ARZNEIMITTEL-FORSCH, V50, P550

[7]

ANDREANI A, 1982, EUR J MED CHEM, V17, P271

[8]

[Anonymous], IMMUNE MODULATION AG

[9]

[Anonymous], 1989, Molecular Cloning: A Laboratory

[10] Antioxidant activity and bioactive compounds of ten Portuguese regional and commercial almond cultivars [J].

Barreira, Joao C. M. ;

Ferreira, Isabel C. F. R. ;

Oliveira, M. Beatriz P. P. ;

Pereira, Jose Alberto .

FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (06) :2230-2235

← 1 2 3 4 →