Thermogelation of PEG-Based Macromolecules of Controlled Architecture

被引：89

作者：

Fechler, Nina ^{[1
]}

Badi, Nezha ^{[1
]}

Schade, Kristin ^{[1
]}

Pfeifer, Sebastian ^{[1
]}

Lutz, Jean-Francois ^{[1
]}

机构：

[1] Fraunhofer Inst Appl Polymer Res, Res Grp Nanotechnol Life Sci, D-14476 Potsdam, Germany

来源：

MACROMOLECULES | 2009年 / 42卷 / 01期

关键词：

OLIGO(ETHYLENE GLYCOL) METHACRYLATE; MEDIATED RADICAL POLYMERIZATION; DILUTE AQUEOUS-SOLUTIONS; THERMOSENSITIVE DIBLOCK COPOLYMERS; LIVING CATIONIC-POLYMERIZATION; AMPHIPHILIC BLOCK-COPOLYMERS; WATER-SOLUBLE POLYSTYRENICS; 2-(2-METHOXYETHOXY)ETHYL METHACRYLATE; ANIONIC POLYMERIZATIONS; POLY(ETHYLENE GLYCOL);

D O I：

10.1021/ma8025173

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The thermogelation of PEG-based Macromolecules of controlled architecture,P(MEO2MA-co-OMEGA) segments were studied for preparing thermoreversible hydrogel networks. The building blocks of these networks were synthesized by using ARTP of MEO2MA and OMEGA475 in the presence of linear or star-shaped PEG macroinitiators. The thermogelation of the macromolecules were studied at higher concentrations in water exhibiting reversible thermothickening properties in aqueous medium. The molecular weights in the experiment were determined by SEC performed at 25°C in THF, and detection was performed with a RI and a UV detector. The obtained optimized architectures showed controllable sol-gel transitions at near physiological temperatures, with a variety of applications in cell biology and tissue engineering.

引用

页码：33 / 36

页数：4

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