The Genomics and Metagenomics of Asthma Severity (GEMAS) Study: Rationale and Design

被引：12

作者：

Perez-Garcia, Javier ^{[1
]}

Hernandez-Perez, Jose M. ^{[2
,3
]}

Gonzalez-Perez, Ruperto ^{[4
,5
]}

Sardon, Olaia ^{[6
,7
]}

Martin-Gonzalez, Elena ^{[1
]}

Espuela-Ortiz, Antonio ^{[1
]}

Mederos-Luis, Elena ^{[4
]}

Callero, Ariel ^{[8
]}

Herrera-Luis, Esther ^{[1
]}

Corcuera, Paula ^{[6
]}

Sanchez-Machin, Inmaculada ^{[4
]}

Poza-Guedes, Paloma ^{[4
,5
]}

Gonzalez Garcia, Luis Manuel ^{[3
,9
]}

Ramirez-Martin, Purificacion ^{[2
]}

Perez-Negrin, Lorenzo ^{[2
]}

Izaguirre-Flores, Hemily ^{[10
]}

Barrios-Recio, Javier ^{[8
]}

Perez-Rodriguez, Eva ^{[8
]}

Alcoba-Florez, Julia ^{[11
]}

Canas, Jose A. ^{[12
,13
]}

Rodrigo Munoz, Jose M. ^{[12
,13
]}

del Pozo, Victoria ^{[12
,13
]}

Korta-Murua, Javier ^{[6
,7
]}

Perez Mendez, Lina I. ^{[13
,14
]}

Hernandez-Ferrer, Mariano ^{[15
,16
]}

Villar, Jesus ^{[13
,17
]}

Lorenzo-Diaz, Fabian ^{[1
,16
]}

Pino-Yanes, Maria ^{[1
,13
,18
]}

机构：

[1] Univ La Laguna, Dept Biochem Microbiol Cell Biol & Genet, Genom & Hlth Grp, San Cristobal De Laguna 38200, Santa Cruz De T, Spain

[2] Hosp Univ NS Candelaria, Pulm Med Serv, Santa Cruz De Tenerife 38010, Spain

[3] Hosp Gen La Palma, Pulm Med Sect, Brena Alta 38713, Santa Cruz De T, Spain

[4] Hosp Univ Canarias, Allergy Dept, San Cristobal De Laguna 38320, Santa Cruz De T, Spain

[5] Hosp Univ Canarias, Allergy Dept, Severe Asthma Unit, San Cristobal De Laguna 38320, Santa Cruz De T, Spain

[6] Hosp Univ Donostia, Div Pediat Resp Med, San Sebastian 20014, Spain

[7] Univ Basque Country, UPV EHU, Dept Pediat, San Sebastian 20014, Spain

[8] Hosp Univ NS Candelaria, Allergy Unit, Santa Cruz De Tenerife 38010, Spain

[9] Hlth Area La Palma, Brena Baja Hlth Ctr, Brena Baja 38711, Santa Cruz De T, Spain

[10] Hosp Univ Canarias, Pulm Med Dept, San Cristobal De Laguna 38320, Santa Cruz De T, Spain

[11] Hosp Univ Nuestra Senora La Candelaria, Unit Serv Microbiol, Santa Cruz De Tenerife 38010, Spain

[12] IIS Fdn Jimenez Diaz, Dept Immunol, Madrid 28040, Spain

[13] Inst Salud Carlos III, CIBER Enfermedades Resp, Madrid 28029, Spain

[14] Hosp Univ NS Candelaria & Primary Care Management, Res Unit, Div Clin Epidemiol & Biostat, Santa Cruz De Tenerife 38010, Spain

[15] Univ La Laguna, Dept Biochem Microbiol Cell Biol & Genet, San Cristobal De Laguna 38200, Santa Cruz De T, Spain

[16] Univ La Laguna, Inst Univ Enfermedades Trop & Salud Publ Canarias, San Cristobal De Laguna 38200, Santa Cruz De T, Spain

[17] Hosp Univ Dr Negrin, Res Unit, Multidisciplinary Organ Dysfunct Evaluat Res Netw, Las Palmas Gran Canaria 35019, Spain

[18] Univ La Laguna, Inst Tecnol Biomed ITB, San Cristobal De Laguna 38200, Santa Cruz De T, Spain

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2020年 / 10卷 / 03期

基金：

欧盟地平线“2020”;

关键词：

asthma; exacerbation; microbiome; genetics; precision medicine; respiratory disease; biomarker; HIGH PREVALENCE; CANARY-ISLANDS; MICROBIOME; PHENOTYPES; SPIROMETRY; CHILDREN;

D O I：

10.3390/jpm10030123

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Asthma exacerbations are a major contributor to the global disease burden, but no significant predictive biomarkers are known. The Genomics and Metagenomics of Asthma Severity (GEMAS) study aims to assess the role of genomics and the microbiome in severe asthma exacerbations. Here, we present the design of GEMAS and the characteristics of patients recruited from March 2018 to March 2020. Different biological samples and demographic and clinical variables were collected from asthma patients recruited by allergy and pulmonary medicine units in several hospitals from Spain. Cases and controls were defined by the presence/absence of severe asthma exacerbations in the past year (oral corticosteroid use, emergency room visits, and/or asthma-related hospitalizations). A total of 137 cases and 120 controls were recruited. After stratifying by recruitment location (i.e., Canary Islands and Basque Country), cases and controls did not differ for most demographic and clinical variables (p> 0.05). However, cases showed a higher proportion of characteristics inherent to asthma exacerbations (impaired lung function, severe disease, uncontrolled asthma, gastroesophageal reflux, and use of asthma medications) compared to controls (p< 0.05). Similar results were found after stratification by recruitment unit. Thereby, asthma patients enrolled in GEMAS are balanced for potential confounders and have clinical characteristics that support the phenotype definition. GEMAS will improve the knowledge of potential biomarkers of asthma exacerbations.

引用

页码：1 / 16

页数：14

共 43 条

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