Anterior Commissure - Posterior Commissure Revisited

Objective: The anterior commissure (AC) and posterior commissure (PC) are the two distinct anatomic structures in the brain which are difficult to observe in detail with conventional MRI, such as a 1.5T MRI system. However, recent advances in ultra-high resolution MRI have enabled us to examine the AC and PC directly. The objective of the present study is to standardize the shape and size of the AC and PC using a 7.0T MRI and to propose a new brain reference Line. Materials and Methods: Thirty-four, 21 males and 13 females, healthy volunteers were enrolled in this study. After determining the center of each AC and PC, we defined the connection of these centers as the central intercommissural Line (CIL). We compared the known extra- and intra-cerebral reference Lines with the CIL to determine the difference in the angles. Additionally, we obtained horizontal Line from flat ground line of look front human. Results: The difference in angle of the CIL and the tangential intercommissural line (TIL) from the horizontal line was 8.7 +/- 5.1 (11 +/- 4.8) and 17.4 +/- 5.2 (19.8 +/- 4.8) degrees in males and females, respectively. The difference in angle between the CIL and canthomeatal line was 10.1 in both male and female, and there was no difference between both sexes. Likewise, there was no significant difference in angle between the CIL and TIL between both sexes (8.3 +/- 1.1 in male and 8.8 +/- 0.7 in female). Conclusion: In this study, we have used 7.0T MRI to define the AC and PC quantitatively and in a more robust manner. We have showed that the CIL is a reproducible reference Line and serves as a standard for the axial images of the human brain.