Tacrolimus ointment in the management of atopic keratoconjunctivitis

Introduction. - Atopic keratoconjunctivitis is associated with eyelid eczema. It may require the use of local corticosteroids which if prolonged can be a source of ocular complications. Tacrolimus is an immunosuppressant used in cutaneous application in atopic dermatitis. The aim of this study was to measure the efficacy and tolerance of tacrolimus 0.1% ointment in palpebral application in atopic keratoconjunctivitis. Patients and methods. - This retrospective, single-center study was conducted between June 2014 and February 2017. Patients with atopic keratoconjunctivitis not controlled by first-line medical treatments were included. The primary endpoint was the evolution of functional signs as assessed by the NEI-VFQ25 and OSDI quality of life scores. Secondary endpoints were visual acuity and local corticosteroid use. Results. - Among the 18 patients included, the mean age was 37.9 +/- 16.8 years. The first follow-up visit was on average 68.3 +/- 55.3 days after initiation of treatment. The NEI-VFQ25 score was significantly improved for seven of its sub-scores (P < 0.05) and the mean OSDI decreased significantly from 52.3 +/- 26.2 to 22.0 +/- 27.0 (P < 0.001) showing a decrease in eye discomfort. A significant reduction was observed in the number of patients using local corticosteroids. There was no significant change in visual acuity. Conclusion. - Tacrolimus ointment 0.1% in palpebral application appears to be an effective treatment for the management of atopic keratoconjunctivitis. (C) 2019 Elsevier Masson SAS. All rights reserved.