Practical enantioselective synthesis of (3S, 4R)-3-hydroxypiperidine-4-carboxylic acid

被引：1
作者：
Line, Nathan J. [1 ]
机构：
[1] AMRI, 26 Corp Circle, Albany, NY 12203 USA
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 20期
关键词：
Piperidine; Aldol; Enantioselective synthesis; Reductive cyclization; INTRAMOLECULAR HYDROAMINATION; ALDOL REACTION;
D O I：
10.1016/j.tetlet.2019.04.023
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical enantioselective synthesis of (3S, 4R)-3-hydroxypiperidine-4-carboxylic acid was accomplished via an unconventional Evans anti-aldol reaction followed by a one-pot azide reduction/reductive cyclization. (C) 2019 Elsevier Ltd. All rights reserved.
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页码：1357 / 1358
页数：2
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