Head and neck squamous cell carcinoma: usefulness of diffusion-weighted MR imaging in the prediction of a neoadjuvant therapeutic effect

被引：65

作者：

Kato, Hiroki ^{[1
]}

Kanematsu, Masayuki ^{[1
,2
]}

Tanaka, Osamu ^{[1
]}

Mizuta, Keisuke ^{[3
]}

Aoki, Mitsuhiro ^{[3
]}

Shibata, Toshiyuki ^{[4
]}

Yamashita, Tomomi ^{[4
]}

Hirose, Yoshinobu ^{[5
]}

Hoshi, Hiroaki ^{[1
]}

机构：

[1] Gifu Univ, Sch Med, Dept Radiol, Gifu 5011194, Japan

[2] Gifu Univ Hosp, High Level Imaging Diag Ctr, Gifu 5011194, Japan

[3] Gifu Univ, Sch Med, Dept Otolaryngol, Gifu 5011194, Japan

[4] Gifu Univ, Grad Sch Med, Dept Oral & Maxillofacial Sci, Gifu 5011194, Japan

[5] Gifu Univ, Sch Med, Dept Pathol, Gifu 5011194, Japan

来源：

EUROPEAN RADIOLOGY | 2009年 / 19卷 / 01期

关键词：

Diffusion-weighted imaging; Squamous cell carcinoma; Head and neck; Neoadjuvant therapy; POSITRON-EMISSION-TOMOGRAPHY; SALIVARY-GLANDS; FDG PET; CANCER; CHOLESTEATOMA; LYMPHOMAS; LESIONS; NODES;

D O I：

10.1007/s00330-008-1108-5

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The purpose of our study was to evaluate the usefulness of diffusion-weighted imaging in predicting the responses to neoadjuvant therapy for head and neck squamous cell carcinomas. Diffusion-weighted, T2-weighted, and gadolinium-enhanced T1-weighted images were obtained from 28 patients with untreated head and neck squamous cell carcinomas with histological proof. A blinded radiologist evaluated the quantitative and qualitative signal intensities and apparent diffusion coefficients (ADCs) in the lesions on each sequence. All patients were treated by neoadjuvant therapies, and the post-therapeutic tumor regression rate was determined. Both the quantitative and qualitative signal intensities on diffusion-weighted images showed positive correlations (r = 0.367 and 0.412, p < .05), and the ADCs showed a weak, inversed correlation (r = -0.384, p < .05) with the tumor regression rates. Diffusion-weighted imaging including an assessment by ADCs may be able to predict tumor response to neoadjuvant therapy for head and neck squamous cell carcinomas.

引用

页码：103 / 109

页数：7

共 32 条

[1] Diffusion-weighted MR imaging of cholesteatoma in pediatric and adult patients who have undergone middle ear surgery [J].