Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease

被引：6

作者：

Wieczorek-Surdacka, Ewa ^{[1
]}

Hanff, Erik ^{[2
]}

Chyrchel, Bernadeta ^{[3
]}

Kuzniewski, Marek ^{[1
]}

Surdacki, Andrzej ^{[3
]}

Tsikas, Dimitrios ^{[2
]}

机构：

[1] Jagiellonian Univ, Dept Nephrol, Med Coll, 15C Kopernika St, PL-31501 Krakow, Poland

[2] Hannover Med Sch, Inst Toxicol, Core Unit Prote, D-30623 Hannover, Germany

[3] Jagiellonian Univ, Dept Cardiol 2, Med Coll, PL-31501 Krakow, Poland

来源：

AMINO ACIDS | 2019年 / 51卷 / 06期

关键词：

ADMA; CAD; CKD; Homoarginine; Kidney; Osteoprotegerin; ALL-CAUSE MORTALITY; CARDIOVASCULAR MORTALITY; RISK-FACTOR; POPULATION; ATHEROSCLEROSIS; PROGRESSION; RATES; MS;

D O I：

10.1007/s00726-019-02738-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High plasma osteoprotegerin (OPG) and asymmetric dimethylarginine (ADMA) and low homoarginine (hArg) predict adverse renal and cardiovascular (CV) outcomes. In patients with chronic kidney disease and stable coronary artery disease, plasma OPG correlated with hArg (r=-0.37, P=0.03) and the hArg/ADMA molar ratio (r=-0.46, P=0.009), which was maintained upon adjustment for renal function. Elevated OPG levels and decreased hArg/ADMA ratios independently predicted 4-year composite CV and renal endpoints (CV death or progression to dialysis). Thus, high OPG and low hArg/ADMA ratio, albeit interrelated, appear to independently contribute to adverse clinical outcome.

引用

页码：977 / 982

页数：6

共 40 条

[1] Reference intervals of plasma homoarginine from the German Gutenberg Health Study [J].

Atzler, Dorothee ;

Appelbaum, Sebastian ;

Cordts, Kathrin ;

Ojeda, Francisco M. ;

Wild, Philipp S. ;

Muenzel, Thomas ;

Blankenberg, Stefan ;

Boeger, Rainer H. ;

Blettner, Maria ;

Beutel, Manfred E. ;

Pfeiffer, Norbert ;

Zeller, Tanja ;

Lackner, Karl J. ;

Schwedhelm, Edzard .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2016, 54 (07) :1231-1237

[2] Homoarginine and Cardiovascular Outcome in the Population-Based Dallas Heart Study [J].

Atzler, Dorothee ;

Gore, M. Odette ;

Ayers, Colby R. ;

Choe, Chi-un ;

Boeger, Rainer H. ;

de Lemos, James A. ;

McGuire, Darren K. ;

Schwedhelm, Edzard .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2014, 34 (11) :2501-2507

[3] Homoarginine - An independent marker of mortality in heart failure [J].

Atzler, Dorothee ;

Rosenberg, Mark ;

Anderssohn, Maike ;

Choe, Chi-un ;

Lutz, Matthias ;

Zugck, Christian ;

Boeger, Rainer H. ;

Frey, Norbert ;

Schwedhelma, Edzard .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 168 (05) :4907-4909

[4] Osteoprotegerin independently predicts mortality in patients with stable coronary artery disease: The CLARICOR trial [J].

Bjerre, Mette ;

Hilden, Jorgen ;

Kastrup, Jens ;

Skoog, Maria ;

Hansen, Jorgen F. ;

Kolmos, Hans J. ;

Jensen, Gorm B. ;

Kjoller, Erik ;

Winkel, Per ;

Flyvbjerg, Allan ;

Gluud, Christian .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2014, 74 (08) :657-664

[5] Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality-An update on patient populations with a wide range of cardiovascular risk [J].

Boeger, Rainer H. ;

Maas, Renke ;

Schulze, Friedrich ;

Schwedhelm, Edzard .

PHARMACOLOGICAL RESEARCH, 2009, 60 (06) :481-487

[6] Homoarginine Levels Are Regulated by L-Arginine: Glycine Amidinotransferase and Affect Stroke Outcome Results From Human and Murine Studies [J].

Choe, Chi-un ;

Atzler, Dorothee ;

Wild, Philipp S. ;

Carter, Angela M. ;

Boeger, Rainer H. ;

Ojeda, Francisco ;

Simova, Olga ;

Stockebrand, Malte ;

Lackner, Karl ;

Nabuurs, Christine ;

Marescau, Bart ;

Streichert, Thomas ;

Mueller, Christian ;

Lueneburg, Nicole ;

De Deyn, Peter P. ;

Benndorf, Ralf A. ;

Baldus, Stephan ;

Gerloff, Christian ;

Blankenberg, Stefan ;

Heerschap, Arend ;

Grant, Peter J. ;

Magnus, Tim ;

Zeller, Tanja ;

Isbrandt, Dirk ;

Schwedhelm, Edzard .

CIRCULATION, 2013, 128 (13) :1451-1461

[7] Homoarginine and Progression of Chronic Kidney Disease: Results from the Mild to Moderate Kidney Disease Study [J].

Drechsler, Christiane ;

Kollerits, Barbara ;

Meinitzer, Andreas ;

Maerz, Winfried ;

Ritz, Eberhard ;

Koenig, Paul ;

Neyer, Ulrich ;

Pilz, Stefan ;

Wanner, Christoph ;

Kronenberg, Florian .

PLOS ONE, 2013, 8 (05)

[8] Asymmetric dimethylarginine and progression of chronic kidney disease:: The mild to moderate kidney disease study [J].

Fliser, D ;

Kronenberg, F ;

Kielstein, JT ;

Morath, C ;

Bode-Böger, SM ;

Haller, H ;

Ritz, E .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (08) :2456-2461

[9] High urinary homoarginine excretion is associated with low rates of all-cause mortality and graft failure in renal transplant recipients [J].

Frenay, Anne-Roos S. ;

Kayacelebi, Arslan Arinc ;

Beckmann, Bibiana ;

Soedamah-Muhtu, Sabita S. ;

de Borst, Martin H. ;

van den Berg, Else ;

van Goor, Harry ;

Bakker, Stephan J. L. ;

Tsikas, Dimitrios .

AMINO ACIDS, 2015, 47 (09) :1827-1836

[10] Development and validation of GC-MS methods for the comprehensive analysis of amino acids in plasma and urine and applications to the HELLP syndrome and pediatric kidney transplantation: evidence of altered methylation, transamidination, and arginase activity [J].

Hanff, Erik ;

Ruben, Stephan ;

Kreuzer, Martin ;

Bollenbach, Alexander ;

Kayacelebi, Arslan Arinc ;

Das, Anibh Martin ;

von Versen-Hoeynck, Frauke ;

von Kaisenberg, Constantin ;

Haffner, Dieter ;

Ueckert, Stefan ;

Tsikas, Dimitrios .

AMINO ACIDS, 2019, 51 (03) :529-547

← 1 2 3 4 →