The life cycle of Ca2+ ions in dendritic spines

被引：538

作者：

Sabatini, BL ^{[1
]}

Oertner, TG ^{[1
]}

Svoboda, K ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USA

来源：

NEURON | 2002年 / 33卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0896-6273(02)00573-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Spine Ca2+ is critical for the induction of synaptic plasticity, but the factors that control Ca2+ handling in dendritic spines under physiological conditions are largely unknown. We studied [Ca2+] signaling in dendritic spines of CA1 pyramidal neurons and find that spines are specialized structures with low endogenous Ca2+ buffer capacity that allows large and extremely rapid [Ca2+] changes. Under physiological conditions, Ca2+ diffusion across the spine neck is negligible, and the spine head functions as a separate compartment on long time scales, allowing localized Ca2+ buildup during trains of synaptic stimuli. Furthermore, the kinetics of Ca2+ sources governs the time course of [Ca2+] signals and may explain the selective activation of long-term synaptic potentiation (LTP) and long-term depression (LTD) by NMDA-R-mediated synaptic Ca2+.

引用

页码：439 / 452

页数：14

共 57 条

[21] Calcium dynamics in single spines during coincident pre- and postsynaptic activity depend on relative timing of back-propagating action potentials and subthreshold excitatory postsynaptic potentials [J].

Koester, HJ ;

Sakmann, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) :9596-9601

[22] Calcium dynamics associated with action potentials in single nerve terminals of pyramidal cells in layer 2/3 of the young rat neocortex [J].

Koester, HJ ;

Sakmann, B .

JOURNAL OF PHYSIOLOGY-LONDON, 2000, 529 (03) :625-646

[23]

Kovalchuk Y, 2000, J NEUROSCI, V20, P1791

[24] CA2+ ENTRY VIA POSTSYNAPTIC VOLTAGE-SENSITIVE CA2+ CHANNELS CAN TRANSIENTLY POTENTIATE EXCITATORY SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS [J].

KULLMANN, DM ;

PERKEL, DJ ;

MANABE, T ;

NICOLL, RA .

NEURON, 1992, 9 (06) :1175-1183

[25] Kinetics of Ca2+ binding to parvalbumin in bovine chromaffin cells:: implications for [Ca2+] transients of neuronal dendrites [J].

Lee, SH ;

Schwaller, B ;

Neher, E .

JOURNAL OF PHYSIOLOGY-LONDON, 2000, 525 (02) :419-432

[26] Differences in Ca2+ buffering properties between excitatory and inhibitory hippocampal neurons from the rat [J].

Lee, SH ;

Rosenmund, C ;

Schwaller, B ;

Neher, E .

JOURNAL OF PHYSIOLOGY-LONDON, 2000, 525 (02) :405-418

[27] A MECHANISM FOR THE HEBB AND THE ANTI-HEBB PROCESSES UNDERLYING LEARNING AND MEMORY [J].

LISMAN, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) :9574-9578

[28] INTRACELLULAR INJECTIONS OF EGTA BLOCK INDUCTION OF HIPPOCAMPAL LONG-TERM POTENTIATION [J].

LYNCH, G ;

LARSON, J ;

KELSO, S ;

BARRIONUEVO, G ;

SCHOTTLER, F .

NATURE, 1983, 305 (5936) :719-721

[29] Supralinear Ca2+ signaling by cooperative and mobile Ca2+ buffering in Purkinje neurons [J].

Maeda, H ;

Ellis-Davies, GCR ;

Ito, K ;

Miyashita, Y ;

Kasai, H .

NEURON, 1999, 24 (04) :989-1002

[30] Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated [J].

Mainen, ZF ;

Malinow, R ;

Svoboda, K .

NATURE, 1999, 399 (6732) :151-155

← 1 2 3 4 5 6 →