Working memory, age and education: A lifespan fMRI study

被引：35

作者：

Archer, Jo A. ^{[1
]}

Lee, Annie ^{[2
]}

Qiu, Anqi ^{[2
,3
,4
]}

Chen, S-H Annabel ^{[1
,5
,6
]}

机构：

[1] Nanyang Technol Univ, Psychol, Singapore, Singapore

[2] Natl Univ Singapore, Dept Biomed Engn, Singapore, Singapore

[3] Natl Univ Singapore, Clin Imaging Res Ctr, Singapore, Singapore

[4] Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore, Singapore

[5] Nanyang Technol Univ, Ctr Res & Dev Learning, Singapore, Singapore

[6] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore

来源：

PLOS ONE | 2018年 / 13卷 / 03期

基金：

英国医学研究理事会;

关键词：

COGNITIVE NEUROSCIENCE; ALZHEIMERS-DISEASE; MIDDLE-AGE; BRAIN; PERFORMANCE; ACTIVATION; METAANALYSIS; ASSOCIATION; CEREBELLUM; RESERVE;

D O I：

10.1371/journal.pone.0194878

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ageing is associated with grey matter atrophy and changes in task-related neural activations. This study investigated the effects of age and education on neural activation during a spatial working memory task in 189 participants aged between 20-80 years old, whilst controlling for grey matter density. Age was related to linear decreases in neural activation in task activated areas, and this effect was no longer significant when adjusting for education or accuracy. Age was also related to cubic increases in neural activation in non-task related areas, such as the temporal gyrus, cuneus and cerebellum when adjusting for accuracy and education. These findings support previous lifespan datasets indicating linear age-related decreases in task activation, but non-linear increases in non-task related areas during episodic memory tasks. The findings also support past studies indicating education offers a form of cognitive reserve through providing a form of neural compensation and highlights the need to consider education in ageing studies.

引用

页数：19

共 52 条

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