Interocular velocity cues elicit vergence eye movements in mice

We stabilize the dynamic visual world on our retina by moving our eyes in response to motion signals. Coordinated movements between the two eyes are characterized as version when both eyes move in the same direction and vergence when the two eyes move in opposite directions. Vergence eye movements are necessary to track objects in three dimensions. In primates they can be elicited by intraocular differences in either spatial signals (disparity) or velocity, requiring the integration of left and right eye inputs. Whether mice are capable of similar behaviors is not known. To address this issue, we measured vergence eye movements in mice using a stereoscopic stimulus known to elicit vergence eye movements in primates. We found that mice also exhibit vergence eye movements, although at a low gain and that the primary driver of these vergence eye movements is interocular motion. Spatial disparity cues alone are ineffective. We also found that the vergence eye movements we observed in mice were robust to silencing visual cortex and to manipulations that disrupt the normal development of binocularity in visual cortex. A sublinear combination of motor commands driven by monocular signals is sufficient to account for our results. NEW & NOTEWORTHY The visual system integrates signals from the left and right eye to generate a representation of the world in depth. The binocular integration of signals may be observed from the coordinated vergence eye movements elicited by object motion in depth. We explored the circuits and signals responsible for these vergence eye movements in rodent and find these vergence eye movements are generated by a comparison of the motion and not spatial visual signals.