Effects of bilateral olfactory bulbectomy on the anterior pituitary corticotropic cell activity in male rats

被引：3
作者：
Marcilhac, A [1 ]
Anglade, G [1 ]
Hery, F [1 ]
Siaud, P [1 ]
机构：
[1] Univ Med, U501 INSERM, Neuroendocrinol Lab, UER Med Nord, F-13916 Marseille 20, France
来源：
HORMONE AND METABOLIC RESEARCH | 1999年 / 31卷 / 07期
关键词：
olfactory bulbectomy; ACTH; proopiomelanocortin; stress; rat anterior pituitary;
D O I：
10.1055/s-2007-978762
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Bilateral olfactory bulbectomy (OB) has drastic biochemical and behavioral effects and is often associated with an increase in plasma corticosterone concentrations. This experiment examined the effects of OB on adrenocorticotropin (ACTH) and corticosterone release under basal and stress conditions and on proopiomelanocortin (POMC) gene expression. Bulbectomy potentiated hypophysal ACTH and adrenal corticosterone release induced by ether stress but had no effect on ACTH release under basal conditions, despite a significant increase of circulating corticosterone. POMC gene expression was stronger (+60%) in OB rats than in sham-operated rats. These results suggest that olfactory bulbectomy substantially altered the negative feed-back exerted by glucocorticoids on anterior pituitary corticotropic cells in the male rat.
引用
收藏
页码：399 / 401
页数：3
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