The zebrafish as a model for studying neuroblastoma

被引：12

作者：

Corallo, Diana ^{[1
]}

Candiani, Simona ^{[2
]}

Ori, Michela ^{[3
]}

Aveic, Sanja ^{[1
]}

Tonini, Gian Paolo ^{[1
]}

机构：

[1] Pediat Res Inst, Neuroblastoma Lab, I-35127 Padua, Italy

[2] Univ Genoa, Dept Earth Environm & Life Sci DISTAV, Cso Europa 26, I-16132 Genoa, Italy

[3] Univ Pisa, Dept Biol, Unit Cell & Dev Biol, SS 12 Abetone & Brennero 4, I-56127 Pisa, Italy

来源：

CANCER CELL INTERNATIONAL | 2016年 / 16卷

关键词：

Neuroblastoma; Zebrafish; Embryonic development; Neural crest; Sympathoadrenal cells; Chromaffin cells; Peripheral sympathetic nervous system; EPITHELIAL-MESENCHYMAL TRANSITIONS; TRANSCRIPTION FACTOR SOX10; CREST CELL-MIGRATION; N-MYC GENE; DORSAL-ROOT; NORADRENERGIC NEURONS; TARGETED DISRUPTION; EMBRYONIC LETHALITY; REPORTER LINES; EXPRESSION;

D O I：

10.1186/s12935-016-0360-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neuroblastoma is a tumor arising in the peripheral sympathetic nervous system and is the most common cancer in childhood. Since most of the cellular and molecular mechanisms underlying neuroblastoma onset and progression remain unknown, the generation of new in vivo models might be appropriate to better dissect the peripheral sympathetic nervous system development in both physiological and disease states. This review is focused on the use of zebrafish as a suitable and innovative model to study neuroblastoma development. Here, we briefly summarize the current knowledge about zebrafish peripheral sympathetic nervous system formation, focusing on key genes and cellular pathways that play a crucial role in the differentiation of sympathetic neurons during embryonic development. In addition, we include examples of how genetic changes known to be associated with aggressive neuroblastoma can mimic this malignancy in zebrafish. Thus, we note the value of the zebrafish model in the field of neuroblastoma research, showing how it can improve our current knowledge about genes and biological pathways that contribute to malignant transformation and progression during embryonic life.

引用

页数：9

共 100 条

[1] Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease [J].

Acloque, Herve ;

Adams, Meghan S. ;

Fishwick, Katherine ;

Bronner-Fraser, Marianne ;

Angela Nieto, M. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (06) :1438-1449

[2] MYCN Promotes the Expansion of Phox2B-Positive Neuronal Progenitors to Drive Neuroblastoma Development [J].

Alam, Goleeta ;

Cui, Hongjuan ;

Shi, Huilin ;

Yang, Liqun ;

Ding, Jane ;

Mao, Ling ;

Maltese, William A. ;

Ding, Han-Fei .

AMERICAN JOURNAL OF PATHOLOGY, 2009, 175 (02) :856-866

[3] Zebrafish Hagoromo Mutants Up-Regulate fgf8 Postembryonically and Develop Neuroblastoma [J].

Amsterdam, Adam ;

Lai, Kevin ;

Komisarczuk, Anna Z. ;

Becker, Thomas S. ;

Bronson, Roderick T. ;

Hopkins, Nancy ;

Lees, Jacqueline A. .

MOLECULAR CANCER RESEARCH, 2009, 7 (06) :841-850

[4] Differentiation and maturation of zebrafish dorsal root and sympathetic ganglion neurons [J].

An, M ;

Luo, RS ;

Henion, PD .

JOURNAL OF COMPARATIVE NEUROLOGY, 2002, 446 (03) :267-275

[5] Newly-derived neuroblastoma cell lines propagated in serum-free media recapitulate the genotype and phenotype of primary neuroblastoma tumours [J].

Bate-Eya, Laurel T. ;

Ebus, Marli E. ;

Koster, Jan ;

den Hartog, Ilona J. M. ;

Zwijnenburg, Danny A. ;

Schild, Linda ;

van der Ploeg, Ida ;

Dolman, M. Emmy M. ;

Caron, Huib N. ;

Versteeg, Rogier ;

Molenaar, Jan J. .

EUROPEAN JOURNAL OF CANCER, 2014, 50 (03) :628-637

[6] Genetically engineered models have advantages over xenografts for preclinical studies [J].

Becher, OJ ;

Holland, EC .

CANCER RESEARCH, 2006, 66 (07) :3355-3358

[7] Analysis of early human neural crest development [J].

Betters, Erin ;

Liu, Ying ;

Kjaeldgaard, Anders ;

Sundstrom, Erik ;

Garcia-Castro, Martin I. .

DEVELOPMENTAL BIOLOGY, 2010, 344 (02) :578-592

[8] Neuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- and phenotypes of patient tumours [J].

Braekeveldt, Noemie ;

Wigerup, Caroline ;

Gisselsson, David ;

Mohlin, Sofie ;

Merselius, My ;

Beckman, Siv ;

Jonson, Tord ;

Borjesson, Anna ;

Backman, Torbjorn ;

Tadeo, Irene ;

Berbegall, Ana P. ;

Ora, Ingrid ;

Navarro, Samuel ;

Noguera, Rosa ;

Pahlman, Sven ;

Bexell, Daniel .

INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (05) :E252-E261

[9] The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system [J].

Britsch, S ;

Li, L ;

Kirchhoff, S ;

Theuring, F ;

Brinkmann, V ;

Birchmeier, C ;

Riethmacher, D .

GENES & DEVELOPMENT, 1998, 12 (12) :1825-1836

[10] The transcription factor Sox10 is a key regulator of peripheral glial development [J].

Britsch, S ;

Goerich, DE ;

Riethmacher, D ;

Peirano, RI ;

Rossner, M ;

Nave, KA ;

Birchmeier, C ;

Wegner, M .

GENES & DEVELOPMENT, 2001, 15 (01) :66-78

← 1 2 3 4 5 6 7 8 9 10 →