Deuteration of indole and N-methylindole by Raney nickel catalysis

被引：0

作者：

Yau, WM ^{[1
]}

Gawrisch, K ^{[1
]}

机构：

[1] NIAAA, LMBB, NIH, Rockville, MD 20852 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1999年 / 42卷 / 07期

关键词：

deuterium; Raney nickel; deuteration; indole; N-methylindole; solid-state NMR;

D O I：

10.1002/(SICI)1099-1344(199907)42:7<709::AID-JLCR235>3.0.CO;2-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Indole and N-methylindole have been partially or fully deuterated by Raney nickel catalyzed H-1-H-2 exchange in a series of deuterated solvents. Perdeuterated indoles have been obtained in water and methanol while compounds that are preferentially deuterated at specific sites were obtained in chloroform, acetone, acetonitrile, ethanol, and isopropanol. The partially deuterated compounds are an important research tool for solid-state NMR studies on proteins.

引用

页码：709 / 713

页数：5

共 23 条

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