Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital stay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB.
机构:
Univ Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USAUniv Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
Askenazi, David J.
Koralkar, Rajesh
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Univ Alabama Birmingham, Dept Publ Hlth, Birmingham, AL 35233 USAUniv Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
Koralkar, Rajesh
Hundley, Hayden E.
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Univ S Alabama, Coll Med, Dept Med, Mobile, AL USAUniv Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
Hundley, Hayden E.
Montesanti, Angela
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Georgia State Univ, Inst Publ Hlth, Ctr Hlth Dev, Atlanta, GA 30303 USAUniv Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
Montesanti, Angela
Parwar, Pushkar
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机构:Univ Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
Parwar, Pushkar
Sonjara, Srdjan
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机构:
Univ Calif San Diego, OBrien Ctr AKI Res, La Jolla, CA 92093 USAUniv Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
Sonjara, Srdjan
Ambalavanan, Namasivayam
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机构:Univ Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
机构:
Columbia Univ Coll Phys & Surg, Dept Nephrol, New York, NY 10032 USAUniv Cincinnati, Sch Med, Cincinnati Childrens Hosp, Med Ctr,Dept Nephrol & Hypertens, Cincinnati, OH 45229 USA
机构:
Austin Hlth, Dept Intens Care, Melbourne, Vic, Australia
Charite, Dept Intens Care & Nephrol, D-13353 Berlin, GermanyAustin Hlth, Dept Intens Care, Melbourne, Vic, Australia
Haase, Michael
Bellomo, Rinaldo
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机构:
Charite, Dept Intens Care & Nephrol, D-13353 Berlin, GermanyAustin Hlth, Dept Intens Care, Melbourne, Vic, Australia
Bellomo, Rinaldo
Haase-Fielitz, Anja
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h-index: 0
机构:
Austin Hlth, Dept Intens Care, Melbourne, Vic, Australia
Charite, Dept Intens Care & Nephrol, D-13353 Berlin, GermanyAustin Hlth, Dept Intens Care, Melbourne, Vic, Australia
机构:
Univ Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USAUniv Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
Askenazi, David J.
Koralkar, Rajesh
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alabama Birmingham, Dept Publ Hlth, Birmingham, AL 35233 USAUniv Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
Koralkar, Rajesh
Hundley, Hayden E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ S Alabama, Coll Med, Dept Med, Mobile, AL USAUniv Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
Hundley, Hayden E.
Montesanti, Angela
论文数: 0引用数: 0
h-index: 0
机构:
Georgia State Univ, Inst Publ Hlth, Ctr Hlth Dev, Atlanta, GA 30303 USAUniv Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
Montesanti, Angela
Parwar, Pushkar
论文数: 0引用数: 0
h-index: 0
机构:Univ Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
Parwar, Pushkar
Sonjara, Srdjan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, OBrien Ctr AKI Res, La Jolla, CA 92093 USAUniv Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
Sonjara, Srdjan
Ambalavanan, Namasivayam
论文数: 0引用数: 0
h-index: 0
机构:Univ Alabama Birmingham, Dept Pediat, Div Nephrol, Birmingham, AL 35233 USA
机构:
Columbia Univ Coll Phys & Surg, Dept Nephrol, New York, NY 10032 USAUniv Cincinnati, Sch Med, Cincinnati Childrens Hosp, Med Ctr,Dept Nephrol & Hypertens, Cincinnati, OH 45229 USA
机构:
Austin Hlth, Dept Intens Care, Melbourne, Vic, Australia
Charite, Dept Intens Care & Nephrol, D-13353 Berlin, GermanyAustin Hlth, Dept Intens Care, Melbourne, Vic, Australia
Haase, Michael
Bellomo, Rinaldo
论文数: 0引用数: 0
h-index: 0
机构:
Charite, Dept Intens Care & Nephrol, D-13353 Berlin, GermanyAustin Hlth, Dept Intens Care, Melbourne, Vic, Australia
Bellomo, Rinaldo
Haase-Fielitz, Anja
论文数: 0引用数: 0
h-index: 0
机构:
Austin Hlth, Dept Intens Care, Melbourne, Vic, Australia
Charite, Dept Intens Care & Nephrol, D-13353 Berlin, GermanyAustin Hlth, Dept Intens Care, Melbourne, Vic, Australia