Histopathological Changes in the Placentas and Fetuses of Mice Infected with Trypanosoma cruzi Isolated from the Myotis nigricans nigricans Bat

被引：7

作者：

Badra, E. S. ^{[1
]}

Sala, M. A. ^{[2
]}

Lopes, R. A. ^{[2
]}

Prado, J. C., Jr. ^{[1
]}

Albuquerque, S. ^{[1
]}

Zucoloto, S. ^{[3
]}

Carraro-Abrahao, A. A. ^{[1
]}

机构：

[1] Univ Sao Paulo, FCFRP, Parasitol Lab, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, Brazil

[2] USP, FORP, Lab Histopatol, Dept Morfol Estomatol & Fisiol, Ribeirao Preto, SP, Brazil

[3] USP, FMRP, Lab Proliferacao Celular, Dept Patol, Ribeirao Preto, SP, Brazil

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2008年 / 139卷 / 2-3期

基金：

巴西圣保罗研究基金会;

关键词：

Chaga's disease; congenital infection; mouse; parasitic infection; Typanosoma cruzi;

D O I：

10.1016/j.jcpa.2008.05.009

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Histopathological changes and placental transmission were studied in the late stages of pregnancy in mice infected with a strain of Trypanosoma cruzi, isolated from a Myolis nigricans nigricans bat. Large amastigote nests were observed in uterine muscles, as well as in decidual and endothelial placental cells. In addition, persistent coagulative and fibrotic Vascular degeneration was observed. Large amastigote burdens were found in giant cells, spongioblasts and endothelial cells within the labyrinthine layer. Transplacental transmission was confirmed in 30% of the fetuses examined, in which amastrigote nests were seen only in striated muscle. During tire acute phase, intrauterine development was impaired as the result of parasitic invasion of the placenta, and fetal mortality rose to 10%. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：108 / 112

页数：5

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