Luminescent organoplatinum(II) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity

被引：108

作者：

Zou, Taotao ^{[1
]}

Lok, Chun-Nam ^{[1
]}

Fung, Yi Man Eva ^{[1
]}

Che, Chi-Ming ^{[1
,2
]}

机构：

[1] Univ Hong Kong, Dept Chem, Inst Mol Funct Mat, State Key Lab Synthet Chem, Hong Kong, Hong Kong, Peoples R China

[2] HKU Shenzhen Inst Res & Innovat, Shenzhen 518053, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 47期

关键词：

METAL-COMPLEXES; STRESS; CISPLATIN; APOPTOSIS; AGENTS;

D O I：

10.1039/c3cc40953h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A panel of luminescent platinum(II) complexes containing bidentate N-heterocyclic carbene ligands selectively localize to the endoplasmic reticulum (ER) domain, induce ER stress and cell apoptosis. Some of them show potent photo-toxicity to cancer cells.

引用

页码：5423 / 5425

页数：3

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