High prevalence of qacA/B carriage among clinical isolates of meticillin-resistant Staphylococcus aureus in Malaysia

被引：31
作者：
Shamsudin, M. N. [1 ,2 ]
Alreshidi, M. A. [1 ]
Hamat, R. A. [1 ]
Alshrari, A. S. [1 ]
Atshan, S. S. [1 ]
Neela, V. [1 ]
机构：
[1] Univ Putra Malaysia, Dept Med Microbiol & Parasitol, Fac Med & Hlth Sci, Serdang 43400, Selangor, Malaysia
[2] Univ Putra Malaysia, Lab Marine Sci & Aquaculture, Inst Biosci, Serdang 43400, Selangor, Malaysia
来源：
JOURNAL OF HOSPITAL INFECTION | 2012年 / 81卷 / 03期
关键词：
Antiseptics; Meticillin-resistant; Staphylococcus aureus; qacA/B; smr; ANTISEPTIC-RESISTANCE; METHICILLIN-RESISTANT; GENES QACA/B; QACB;
D O I：
10.1016/j.jhin.2012.04.015
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The minimum inhibitory concentrations (MICs) of 60 meticillin-resistant Staphylococcus aureus (MRSA) isolates from Malaysia to three antiseptic agents - benzalkonium chloride (BZT), benzethonium chloride (BAC) and chlorhexidine digluconate (CHG) - were determined. All isolates had MICs ranging from 0.5 to 2 mg/L. Antiseptic resistance genes qacA/B and smr were detected in 83.3% and 1.6% of the isolates, respectively. Carriage of qacA/B correlated with reduced susceptibility to CHG and BAC. This is the first report of the prevalence of qacA/B and smr gene carriage in Malaysian MRSA isolates, with a high frequency of qacA/B carriage. The presence of these antiseptic resistance genes and associated reduced susceptibility to antiseptic agents may have clinical implications. (C) 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：206 / 208
页数：3
相关论文
共 50 条
  • [31] Three years' experience of screening for meticillin-resistant Staphylococcus aureus in obstetrics
    Gray, J. W.
    Suviste, J.
    JOURNAL OF HOSPITAL INFECTION, 2013, 83 (01) : 61 - 63
  • [32] Effects of subinhibitory concentrations of chlorhexidine and mupirocin on biofilm formation in clinical meticillin-resistant Staphylococcus aureus
    Park, K-H
    Jung, M.
    Kim, D. Y.
    Lee, Y-M
    Lee, M. S.
    Ryu, B-H
    Hong, S., I
    Hong, K-W
    Bae, I-G
    Cho, O-H
    JOURNAL OF HOSPITAL INFECTION, 2020, 106 (02) : 295 - 302
  • [33] Antimicrobial activity of β-lapachone encapsulated into liposomes against meticillin-resistant Staphylococcus aureus and Cryptococcus neoformans clinical strains
    Cavalcanti, I. M. F.
    Pontes-Neto, J. G.
    Kocerginsky, P. O.
    Bezerra-Neto, A. M.
    Lima, J. L. C.
    Lira-Nogueira, M. C. B.
    Maciel, M. A. V.
    Neves, R. P.
    Pimentel, M. F.
    Santos-Magalhaes, N. S.
    JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2015, 3 (02) : 103 - 108
  • [34] Current concepts on the virulence mechanisms of meticillin-resistant Staphylococcus aureus
    Watkins, Richard R.
    David, Michael Z.
    Salata, Robert A.
    JOURNAL OF MEDICAL MICROBIOLOGY, 2012, 61 (09) : 1179 - 1193
  • [35] Nasal carriage of meticillin-resistant Staphylococcus aureus among children living with HIV attending Infectious Diseases Clinics in Kano, Nigeria
    Sadauki, Aisha Habib
    Olorukooba, Abdulhakeem Abayomi
    Balogun, Muhammad Shakir
    Dalhat, Mahmood Muazu
    Waziri, Hyelshilni
    Abdulaziz, Mukhtar Muhammad
    Umeokonkwo, Chukwuma David
    Hassan-Hanga, Fatimah
    Sabitu, Kabir
    INFECTION PREVENTION IN PRACTICE, 2022, 4 (02)
  • [36] Epidemiology of meticillin-resistant Staphylococcus aureus (MRSA) in Latin America
    Guzman-Blanco, Manuel
    Mejia, Carlos
    Isturiz, Raul
    Alvarez, Carlos
    Bavestrello, Luis
    Gotuzzo, Eduardo
    Labarca, Jaime
    Luna, Carlos M.
    Rodriguez-Noriega, Eduardo
    Salles, Mauro J. C.
    Zurita, Jeannete
    Seas, Carlos
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2009, 34 (04) : 304 - 308
  • [37] An outbreak of catalase-negative meticillin-resistant Staphylococcus aureus
    Del'Alamo, L.
    d'Azevedo, P. A.
    Strob, A. J.
    Rodriguez-Lopez, D. V.
    Monteiro, J.
    Andrade, S. S.
    Pignatari, A. C. C.
    Gales, A. C.
    JOURNAL OF HOSPITAL INFECTION, 2007, 65 (03) : 226 - 230
  • [38] Investigation of meticillin-resistant Staphylococcus aureus in pigs used for research
    Sergio, Darvi Michell Bufete
    Koh, Tse Hsien
    Hsu, Li-Yang
    Ogden, Bryan Emmett
    Goh, Angela L. H.
    Chow, Pierce K. H.
    JOURNAL OF MEDICAL MICROBIOLOGY, 2007, 56 (08) : 1107 - 1109
  • [39] Virulence determinants in community and hospital meticillin-resistant Staphylococcus aureus
    Tristan, Anne
    Ferry, Tristan
    Durand, Geraldine
    Dauwalder, Olivier
    Bes, Michele
    Lina, Gerard
    Vandenesch, Francois
    Etienne, Jerome
    JOURNAL OF HOSPITAL INFECTION, 2007, 65 : 105 - 109
  • [40] Strain relatedness of meticillin-resistant Staphylococcus aureus isolates recovered from patients with repeated bacteraemia
    Liao, C-H.
    Lai, C-C.
    Chen, S-Y.
    Huang, Y-T.
    Hsueh, P-R.
    CLINICAL MICROBIOLOGY AND INFECTION, 2010, 16 (05) : 463 - 469
12345