High prevalence of qacA/B carriage among clinical isolates of meticillin-resistant Staphylococcus aureus in Malaysia

被引：31
作者：
Shamsudin, M. N. [1 ,2 ]
Alreshidi, M. A. [1 ]
Hamat, R. A. [1 ]
Alshrari, A. S. [1 ]
Atshan, S. S. [1 ]
Neela, V. [1 ]
机构：
[1] Univ Putra Malaysia, Dept Med Microbiol & Parasitol, Fac Med & Hlth Sci, Serdang 43400, Selangor, Malaysia
[2] Univ Putra Malaysia, Lab Marine Sci & Aquaculture, Inst Biosci, Serdang 43400, Selangor, Malaysia
来源：
JOURNAL OF HOSPITAL INFECTION | 2012年 / 81卷 / 03期
关键词：
Antiseptics; Meticillin-resistant; Staphylococcus aureus; qacA/B; smr; ANTISEPTIC-RESISTANCE; METHICILLIN-RESISTANT; GENES QACA/B; QACB;
D O I：
10.1016/j.jhin.2012.04.015
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The minimum inhibitory concentrations (MICs) of 60 meticillin-resistant Staphylococcus aureus (MRSA) isolates from Malaysia to three antiseptic agents - benzalkonium chloride (BZT), benzethonium chloride (BAC) and chlorhexidine digluconate (CHG) - were determined. All isolates had MICs ranging from 0.5 to 2 mg/L. Antiseptic resistance genes qacA/B and smr were detected in 83.3% and 1.6% of the isolates, respectively. Carriage of qacA/B correlated with reduced susceptibility to CHG and BAC. This is the first report of the prevalence of qacA/B and smr gene carriage in Malaysian MRSA isolates, with a high frequency of qacA/B carriage. The presence of these antiseptic resistance genes and associated reduced susceptibility to antiseptic agents may have clinical implications. (C) 2012 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：206 / 208
页数：3
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