Dammarane Glycosides from the Root of Machilus yaoshansis

被引：44

作者：

Gan, Maoluo ^{[1
,2
,3
]}

Liu, Mingtao ^{[1
,2
]}

Gan, Lishe ^{[4
]}

Lin, Sheng ^{[1
,2
]}

Liu, Bo ^{[1
,2
]}

Zhang, Yanling ^{[1
,2
]}

Zi, Jiachen ^{[1
,2
]}

Song, Weixia ^{[1
,2
]}

Shi, Jiangong ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[4] Zhejiang Univ, Coll Pharmaceut Sci, Inst Modern Chinese Med, Hangzhou 310058, Zhejiang, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 07期

关键词：

ELECTRONIC CIRCULAR-DICHROISM; ABSOLUTE-CONFIGURATION; GYNOSTEMMA-PENTAPHYLLUM; THEORETICAL CALCULATION; TRITERPENE SAPONINS; STEM BARKS; DERIVATIVES; ASSIGNMENT; CELLS; CONSTITUENTS;

D O I：

10.1021/np300310a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine new dammarane triterpene glycosides (1-3 and 8-13) and 12 known analogues have been isolated from an ethanol extract of the roots of Machilus yaoshansis. Compounds 1-7 have an uncommon 20,23-dihydroxydammar-24-en-21-oic acid-21,23-lactone moiety that was previously reported in compounds isolated from Gynostemma pentaphyllum. The configurations of the lactone moieties in 1-3 were determined by comparison of the experimental ECD spectra of 1-3 and the hydrolysates, 1a and 1b, with the corresponding calculated ECD spectra. On the basis of NMR and ECD data analysis of 1-7, the previously reported C-20 and C-23 configurations of 4-7 and related derivatives from Gynostemma pentaphyllum were revised. In addition, the application of NMR data and Cotton effects to the determination of the relative and absolute configurations of the gamma-lactone moiety in 3 beta,20,23-trihydroxydammar-24-en-21-oic acid-21,23-lactone derivatives is discussed.

引用

页码：1373 / 1382

页数：10

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