Near Infrared Light Triggered Release of Biomacromolecules from Hydrogels Loaded with Upconversion Nanoparticles

被引：358

作者：

Yan, Bin ^{[2
]}

Boyer, John-Christopher ^{[1
]}

Habault, Damien ^{[2
]}

Branda, Neil R. ^{[1
]}

Zhao, Yue ^{[2
]}

机构：

[1] Simon Fraser Univ, Dept Chem, 4D LABS, Burnaby, BC V5A 1S6, Canada

[2] Univ Sherbrooke, Dept Chim, Sherbrooke, PQ J1K 2R1, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 40期

基金：

加拿大自然科学与工程研究理事会;

关键词：

UPCONVERTING NANOPARTICLES; PHOTODEGRADABLE HYDROGELS; RESPONSIVE HYDROGELS; CAGED COMPOUNDS; IN-VITRO; PROTEIN; DELIVERY; PH; BIODISTRIBUTION; ENCAPSULATION;

D O I：

10.1021/ja308876j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using a photosensitive hybrid hydrogel loaded with upconversion nanoparticles (UCNPs), we show that continuous-wave near-infrared (NIR) light (980 nm) can be used to induce the gel-sol transition and release large, inactive biomacromolecules (protein and enzyme) entrapped in the hydrogel into aqueous solution "on demand", where their bioactivity is recovered. This study is a new demonstration and development in harnessing the unique multiphoton effect of UCNPs for photosensitive materials of biomedical interest.

引用

页码：16558 / 16561

页数：4

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