The Role of Hyaluronan and the Extracellular Matrix in Islet Inflammation and Immune Regulation

被引：75

作者：

Bollyky, Paul L. ^{[1
]}

Bogdani, Marika ^{[2
]}

Bollyky, Jennifer B. ^{[1
]}

Hull, Rebecca L. ^{[3
,4
]}

Wight, Thomas N. ^{[1
]}

机构：

[1] Benaroya Res Inst Virginia Mason, Seattle, WA 98101 USA

[2] Pacific NW Diabet Res Inst, Seattle, WA USA

[3] VA Puget Sound Hlth Care Syst, Div Metab Endocrinol & Nutr, Seattle, WA USA

[4] Univ Washington, Seattle, WA 98195 USA

来源：

CURRENT DIABETES REPORTS | 2012年 / 12卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Hyaluronan; TSG-6; CD44; TLR2; TLR4; Toll-like receptors; Foxp3; Regulatory T-cells; TR1; Treg; IL-10; TGF-beta; Extracellular matrix; Diabetes; Islets; Islet inflammation; Immune regulation; BETA-CELL DESTRUCTION; T-CELLS; PANCREATIC-ISLETS; BASEMENT-MEMBRANE; CROSS-LINKING; BINDING PROTEINS; HEPARAN-SULFATE; DENDRITIC CELLS; NOD MICE; CD44;

D O I：

10.1007/s11892-012-0297-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 1 diabetes (T1D) is a disease that in most individuals results from autoimmune attack of a single tissue type, the pancreatic islet. A fundamental, unanswered question in T1D pathogenesis is how the islet tissue environment influences immune regulation. This crosstalk is likely to be communicated through the extracellular matrix (ECM). Here, we review what is known about the ECM in insulitis and examine how the tissue environment is synchronized with immune regulation. In particular, we focus on the role of hyaluronan (HA) and its interactions with Foxp3+ regulatory T-cells (Treg). We propose that HA is a "keystone molecule" in the inflammatory milieu and that HA, together with its associated binding proteins and receptors, is an appropriate point of entry for investigations into how ECM influences immune regulation in the islet.

引用

页码：471 / 480

页数：10

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