Intratumoral stages of metastatic cells: A synthesis of ontogeny, Rho/Rac GTPases, epithelial-mesenchymal transitions, and more

被引：14
作者：
Bustelo, Xose R. [1 ,2 ]
机构：
[1] Univ Salamanca, CSIC, Ctr Invest Canc, E-37008 Salamanca, Spain
[2] Univ Salamanca, CSIC, Inst Biol Mol & Celular Canc, E-37008 Salamanca, Spain
来源：
BIOESSAYS | 2012年 / 34卷 / 09期
关键词：
cancer; cytoskeleton; inflammation; migration; stromal cells; BREAST-CANCER METASTASIS; GENE-EXPRESSION; FEEDBACK LOOP; TUMOR-METASTASIS; MYELOID CELLS; PROMOTES; INVASION; PROGRESSION; ACTIVATION; CARCINOMA;
D O I：
10.1002/bies.201200041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metastasis is one of the clinical parameters that has a strong negative influence on the prognosis of cancer patients. In recent years, significant advances have furthered our understanding of this process at the molecular and biological levels. This paper will discuss recent discoveries relating to the earliest, intra-tumoral stages of metastasis in cancer cells, specifically focusing on: (i) the development of metastatic traits during primary tumorigenesis; (ii) intrinsic and extrinsic cancer cell programs associated with malignant traits; (iii) the intra-tumoral migration patterns of cancer cells and the dynamic roles played by the Rho/Rac GTPases and epithelial-mesenchymal transitions in this process; and (iv) the genetic strategies used by metastatic cancer cells to promote intra-tumoral cell migration and their subsequent escape to peripheral tissues. Finally, the therapeutic and diagnostic relevance of this information will be discussed, as well as potential future developments.
引用
收藏
页码：748 / 759
页数：12
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