Aberrant epigenetic regulation of bromodomain Brd4 in human colon cancer

被引：52

作者：

Rodriguez, R. M. ^{[1
]}

Huidobro, C. ^{[1
]}

Urdinguio, R. G. ^{[1
]}

Mangas, C. ^{[1
]}

Soldevilla, B. ^{[2
]}

Dominguez, G. ^{[2
]}

Bonilla, F. ^{[2
]}

Fernandez, A. F. ^{[1
]}

Fraga, M. F. ^{[1
,3
]}

机构：

[1] Univ Oviedo, Canc Epigenet Lab, HUCA, IUOPA, Oviedo, Spain

[2] Univ Autonoma Madrid, Hosp Univ Puerta de Hierro, Dept Med Oncol, Madrid, Spain

[3] Ctr Nacl Biotecnol CNB CSIC, Dept Immunol & Oncol, Madrid, Spain

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2012年 / 90卷 / 05期

关键词：

Colon cancer; DNA methylation; BRD4; Tumor suppressor gene; PROTEIN BRD4; ACETYLATED CHROMATIN; S-PHASE; PROGRESSION; EXPRESSION; CARCINOMA;

D O I：

10.1007/s00109-011-0837-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The bromodomain protein BRD4 is involved in cell proliferation and cell cycle progression, primarily through its role in acetylated chromatin-dependent regulation of transcription at targeted loci. Here, we show that BRD4 is frequently downregulated by aberrant promoter hypermethylation in human colon cancer cell lines and primary tumors. Ectopic re-expression of BRD4 in these colon cancer cell lines markedly reduced in vivo tumor growth, suggesting a role of BRD4 in human colon cancer.

引用

页码：587 / 595

页数：9

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