QUANTITATIVE EVALUATION OF RETINAL TUMOR VOLUME IN MOUSE MODEL OF RETINOBLASTOMA BY USING ULTRA HIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY

被引：4

作者：

Ruggeri, Marco ^{[1
]}

Wehbe, Hassan ^{[1
]}

Tsechpenakis, Gavriil ^{[2
]}

Jiao, Shuliang ^{[1
]}

Jockovich, Maria Elena ^{[1
]}

Cebulla, Colleen ^{[1
]}

Hernandez, Eleut ^{[1
]}

Murray, Timothy G. ^{[1
]}

Puliafito, Carmen A. ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USA

[2] Univ Miami, Dept Elect & Comp Engn, Coral Gables, FL 33124 USA

来源：

JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES | 2008年 / 1卷 / 01期

关键词：

3D imaging; retina; mouse models; optical coherence tomography; image segmentation;

D O I：

10.1142/S1793545808000066

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

An ultra high resolution spectral-domain optical coherence tomography (SD-OCT) together with an advanced animal restraint and positioning system was built for noninvasive non-contact in vivo three-dimensional imaging of rodent models of ocular diseases. The animal positioning system allowed the operator to rapidly locate and switch the areas of interest on the retina. This function together with the capability of precise spatial registration provided by the generated OCT fundus image allows the system to locate and compare the same lesion (retinal tumor in the current study) at different time point throughout the entire course of the disease progression. An algorithm for fully automatic segmentation of the tumor boundaries and calculation of tumor volume was developed. The system and algorithm were successfully applied to monitoring retinal tumor growth quantitatively over time in the LHBETATAG mouse model of retinoblastoma.

引用

页码：17 / 28

页数：12

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