Metastasizing Middle Ear Carcinoid: An Unusual Case Report, With Focus on Ultrastructural and Immunohistochemical Findings

被引:9
作者
Salzman, Richard [2 ]
Starek, Ivo [1 ,4 ]
Ticha, Vlastislava [3 ]
Skalova, Alena [5 ]
Kucera, Jiri
机构
[1] Palacky Univ, Fac Hosp, ENT Dept, CR-77147 Olomouc, Czech Republic
[2] Derriford Hosp, ENT Dept, Plymouth PL6 8DH, Devon, England
[3] Palacky Univ, Fac Hosp, Dept Pathol, CR-77147 Olomouc, Czech Republic
[4] Palacky Univ, Fac Med, CR-77147 Olomouc, Czech Republic
[5] Charles Univ Prague, Fac Med, Dept Pathol, Plzen, Czech Republic
关键词
Carcinoid; Lymph node; Metastasis; Middle ear; Parotid gland; PULMONARY CARCINOIDS; TUMOR; ADENOMA; RECURRENCE; PREDICTOR; NEOPLASMS; FEATURES; LIGHT;
D O I
10.1097/MAO.0b013e3182693888
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: There are only 4 unequivocal cases of metastasizing middle ear carcinoid previously reported. Objective: To present a case of metastasizing middle ear carcinoid, to review previously reported cases, and to discuss the clinical nature of this tumor, which is similar to "orthotopic" carcinoids bearing definite metastatic potential. Study Design: Case report. Patient, Intervention, Results: We present a 72-year-old woman who developed ipsilateral parotid gland and cervical lymph node metastases 8 and 11 months after surgical removal of a primary middle ear lesion. She subsequently required 2 revision procedures and radiotherapy for local recurrences. Her case was complicated by nonsurgically induced permanent facial nerve paralysis, the cause of which remains obscure. At the end of the 8-year follow-up, the patient was alive with locally, recurrent tumor eroding the cranial base and invading the posterior intracranial fossa but with no signs of metastases. Main Outcome Measures: Light microscopy and immunohistochemical analysis. Conclusion: Considering the reported high rate of recurrence and their consequent metastases, a middle ear carcinoid should be classified as a neuroendocrine low-grade carcinoma.
引用
收藏
页码:1418 / 1421
页数:4
相关论文
共 50 条
[41]   Late Recurrence of a Rare Middle Ear Neuroendocrine Tumor With an Intracranial Extension to the Temporal Fossa: A Case Report [J].
Kvascevicius, Lukas ;
Lesinskas, Eugenijus ;
Petroska, Donatas ;
Kvascevicius, Robertas ;
Satinskiene, Inga .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (04)
[42]   Mucosal Melanoma of the Middle Ear Cavity and Eustachian Tube: A Case Report, Literature Review, and Focus on Surgical Technique [J].
Peters, Geoffrey ;
Arriaga, Moises A. ;
Nuss, Daniel W. ;
Pou, Anna M. ;
DiLeo, Michael ;
Scrantz, Kelly .
OTOLOGY & NEUROTOLOGY, 2012, 33 (02) :239-243
[43]   A primary pancreatic carcinoid tumour with unusual clinical complaints: A case report [J].
Saint-Marc O. ;
Cogliandolo A. ;
Pozzo A. ;
Pidoto R.R. .
World Journal of Surgical Oncology, 2 (1)
[44]   Aggressive low grade middle ear adenocarcinoma with multiple recurrences: a case report [J].
Elhefnawy, Nadia G. .
DIAGNOSTIC PATHOLOGY, 2011, 6
[45]   Middle Ear Welding Injury: Case Report and Literature Review [J].
Bruno, Gabriele ;
Carlotto, Elena ;
Bramardi, Fabio ;
Franco, Elisa ;
Lanzillota, Alessia ;
Lerda, Walter ;
Naqe, Nertila ;
Ponzo, Silvia .
JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, 2024, 20 (05) :462-467
[46]   Temporal bone meningioma involving the middle ear: A case report [J].
Ricciardiello, Filippo ;
Fattore, Lucia ;
Liguori, Maria Ester ;
Oliva, Flavia ;
Luce, Amalia ;
Abate, Teresa ;
Caraglia, Michele ;
Pianese, Annalisa ;
Raucci, Aldo Falco .
ONCOLOGY LETTERS, 2015, 10 (04) :2249-2252
[47]   Myospherulosis of the middle ear: A case report and systematic review of literature [J].
Dogiparthi, Jaswanthi ;
Tu, Leona J. ;
Volner, Keith D. ;
Fisch, Adam S. ;
Cohen, Michael S. .
OTOLARYNGOLOGY CASE REPORTS, 2024, 32
[48]   Middle Ear Neuroendocrine Adenoma: A Case Report and Literature Review [J].
Bruschini, Luca ;
Canelli, Rachele ;
Cambi, Christina ;
Fiacchini, Giacomo ;
Berrettini, Stefano ;
Forli, Francesca .
CASE REPORTS IN OTOLARYNGOLOGY, 2020, 2020
[49]   Tuberculosis of the parotid gland and the middle ear: a rare case report [J].
Banerjee P.K. ;
Jain A. ;
Manjunath D. .
The Egyptian Journal of Otolaryngology, 2015, 31 (3) :196-198
[50]   Middle ear adenoma with neuroendocrine differentiation: Report of a rare case [J].
Yadav, Shakti Kumar ;
Naeem, Roshina ;
Sharma, Amitabh ;
Singh, Sompal ;
Sarin, Namrata ;
Pruthi, Sonam Kumar .
INDIAN JOURNAL OF CANCER, 2020, 57 (01) :98-101