REM sleep is associated with white matter integrity in cognitively healthy, older adults

被引:24
作者
Altendahl, Marie [1 ,6 ]
Cotter, Devyn L. [1 ]
Staffaroni, Adam M. [1 ]
Wolf, Amy [1 ]
Mumford, Paige [1 ]
Cobigo, Yann [1 ]
Casaletto, Kaitlin [1 ]
Elahi, Fanny [1 ]
Ruoff, Leslie [2 ]
Javed, Samirah [1 ,3 ]
Bettcher, Brianne M. [1 ,4 ,5 ]
Fox, Emily [1 ]
You, Michelle [1 ]
Saloner, Rowan [1 ,7 ]
Neylan, Thomas C. [1 ,2 ,3 ]
Kramer, Joel H. [1 ,3 ]
Walsh, Christine M. [1 ]
机构
[1] Univ Calif San Francisco, Weill Inst Neurosci, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
[2] San Francisco VA Med Ctr, Stress & Hlth Res Program, Dept Mental Hlth, San Francisco, CA USA
[3] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
[4] Univ Colorado, Dept Neurosurg, Rocky Mt Alzheimers Dis Ctr, Anschutz Med Campus, Aurora, CO USA
[5] Univ Colorado, Dept Neurol, Rocky Mt Alzheimers Dis Ctr, Anschutz Med Campus, Aurora, CO USA
[6] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
[7] San Diego State Univ Univ Calif San Diego Joint D, San Diego, CA USA
来源
PLOS ONE | 2020年 / 15卷 / 07期
关键词
CORPUS-CALLOSUM; RISK-FACTOR; DIFFUSION; DURATION; SYSTEM; APNEA; IMPAIRMENT; DEMENTIA; PATTERNS; DECLINE;
D O I
10.1371/journal.pone.0235395
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
There is increasing awareness that self-reported sleep abnormalities are negatively associated with brain structure and function in older adults. Less is known, however, about how objectively measured sleep associates with brain structure. We objectively measured at-home sleep to investigate how sleep architecture and sleep quality related to white matter microstructure in older adults. 43 cognitively normal, older adults underwent diffusion tensor imaging (DTI) and a sleep assessment within a six-month period. Participants completed the PSQI, a subjective measure of sleep quality, and used an at-home sleep recorder (Zeo, Inc.) to measure total sleep time (TST), sleep efficiency (SE), and percent time in light sleep (LS), deep sleep (DS), and REM sleep (RS). Multiple regressions predicted fractional anisotropy (FA) and mean diffusivity (MD) of the corpus callosum as a function of total PSQI score, TST, SE, and percent of time spent in each sleep stage, controlling for age and sex. Greater percent time spent in RS was significantly associated with higher FA (beta = 0.41,p= 0.007) and lower MD (beta = -0.30,p= 0.03). Total PSQI score, TST, SE, and time spent in LS or DS were not significantly associated with FA or MD (p>0.13). Percent time spent in REM sleep, but not quantity of light and deep sleep or subjective/objective measures of sleep quality, positively predicted white matter microstructure integrity. Our results highlight an important link between REM sleep and brain health that has the potential to improve sleep interventions in the elderly.
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页数:16
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