Fine Chemical Synthesis of Poly(ADP-Ribose)

被引：0

作者：

Morihiro, Kunihiko

机构：

来源：

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 2018年 / 76卷 / 12期

关键词：

RIBOSE;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Poly(ADP-ribose) is an important biomolecule that regulates various cellular events such as DNA-damage repair, apoptosis, and transcription. The length of the poly(ADP-ribose) chains ranges from 2 to 400 units and branching at the ribose moiety occurs once every 20 to 50 units. To elucidate the biological role of poly(ADP-ribose), well-defined fragments of poly(ADP-ribose) are essential. However, traditional enzymatic synthesis of poly(ADP-ribose) leads to nonhomogeneous products with a broad distribution of the chain length and branching points. Chemical synthesis will allow for the preparation of poly(ADP-ribose) with a well-defined structure.

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页码：1360 / 1362

页数：3

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