Animal models of obesity and diabetes mellitus

被引：640

作者：

Kleinert, Maximilian ^{[1
,2
,3
,4
]}

Clemmensen, Christoffer ^{[1
,2
,3
]}

Hofmann, Susanna M. ^{[3
,5
,6
]}

Moore, Mary C. ^{[7
]}

Renner, Simone ^{[3
,8
]}

Woods, Stephen C. ^{[9
]}

Huypens, Peter ^{[3
,10
]}

Beckers, Johannes ^{[3
,10
,11
]}

de Angelis, Martin Hrabe ^{[3
,10
,11
,14
]}

Schuermann, Annette ^{[3
,12
,13
]}

Bakhti, Mostafa ^{[3
,5
,13
]}

Klingenspor, Martin ^{[15
,16
]}

Heiman, Mark ^{[17
]}

Cherrington, Alan D. ^{[7
]}

Ristow, Michael ^{[18
]}

Lickert, Heiko ^{[3
,5
,13
]}

Wolf, Eckhard ^{[3
]}

Havel, Peter J. ^{[19
,20
]}

Mueller, Timo D. ^{[1
,2
,3
]}

Tschoep, Matthias H. ^{[1
,2
,3
]}

机构：

[1] German Res Ctr Environm Hlth GmbH, Inst Diabet & Obes, Helmholtz Diabet Ctr, Helmholtz Zentrum Munchen, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany

[2] Tech Univ Munich, Div Metab Dis, Dept Med, D-80333 Munich, Germany

[3] German Ctr Diabet Res DZD, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany

[4] Univ Copenhagen, Sect Mol Physiol, Dept Nutr Exercise & Sports, Fac Sci, DK-2200 Copenhagen, Denmark

[5] German Res Ctr Environm Hlth GmbH, Inst Diabet & Regenerat Res, Helmholtz Zentrum Munchen, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany

[6] Klinikum Ludwig Maximilians Univ Munchen, Med Klin & Poliklin 4, Ziemssenstr 1, D-80336 Munich, Germany

[7] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37212 USA

[8] Ludwig Maximilan Univ Munchen, Gene Ctr, Chair Mol Anim Breeding & Biotechnol, Feodor Lynen Str 25, D-81377 Munich, Germany

[9] Univ Cincinnati, Metab Dis Inst, Dept Psychiat & Behav Neurosci, Coll Med, 2170 East Galbraith Rd, Cincinnati, OH 45237 USA

[10] German Res Ctr Environm Hlth GmbH, Inst Expt Genet, Helmholtz Zentrum Munchen, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany

[11] Tech Univ Munich, Chair Expt Genet, D-85354 Freising Weihenstephan, Germany

[12] German Inst Human Nutr Potsdam Rehbrucke, Dept Expt Diabetol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany

[13] German Res Ctr Environm Hlth GmbH, Inst Stem Cell Res, Helmholtz Zentrum Munchen, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany

[14] Tech Univ Munich, Chair Mol Nutr Med, TUM Sch Life Sci Weihenstephan, Gregor Mendel Str 2, D-85354 Freising Weihenstephan, Germany

[15] Tech Univ Munich, Else Kroner Fresenius Ctr Nutr Med, D-85354 Freising Weihenstephan, Germany

[16] Tech Univ Munich, Inst Food Hlth, D-85354 Freising Weihenstephan, Germany

[17] MicroBiome Therapeut, 1316 Jefferson Ave, New Orleans, LA 70115 USA

[18] Swiss Fed Inst Technol, Inst Translat Med, Energy Metab Lab, CH-8603 Zurich, Switzerland

[19] Univ Calif Davis, Dept Mol Biosci, Sch Vet Med, 3135 Meyer Hall, Davis, CA 95616 USA

[20] Univ Calif Davis, Dept Nutr, 3135 Meyer Hall, Davis, CA 95616 USA

来源：

NATURE REVIEWS ENDOCRINOLOGY | 2018年 / 14卷 / 03期

关键词：

HIGH-FAT-DIET; INDUCED INSULIN-RESISTANCE; HEPATIC GLUCOSE-UPTAKE; BODY-MASS INDEX; BETA-CELL DEDIFFERENTIATION; ZEBRAFISH DANIO-RERIO; BROWN ADIPOSE-TISSUE; INHIBITS FOOD-INTAKE; UCD-T2DM RAT MODEL; TRANSGENIC PIGS;

D O I：

10.1038/nrendo.2017.161

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions. In this Review, we consolidate the key information on the currently available animal models of obesity and diabetes and highlight the advantages, limitations and important caveats of each of these models.

引用

页码：140 / 162

页数：23

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