Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging

被引：58
作者：
Le, DA
Lipton, SA [1 ]
机构：
[1] Burnham Inst, Ctr Neurosci & Aging, La Jolla, CA 92037 USA
[2] Massachusetts Gen Hosp, Stroke & Neurovasc Regulat Lab, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Stroke & Neurovasc Regulat Lab, Boston, MA USA
来源：
DRUGS & AGING | 2001年 / 18卷 / 10期
关键词：
D O I：
10.2165/00002512-200118100-00001
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The N-methyl-D-aspartate (NMDA) receptor complex is a subtype of glutamate receptor and its dysfunction is involved in many neurological disorders associated with aging, including chronic pain, depression, stroke and Parkinson's disease. Multiple clinical trials using NMDA receptor antagonists have been aborted mainly due to the severe psychomimetic adverse effects of these drugs that occur before concentrations can reach an adequate level in the brain. In this review, we present the evidence that clinically safer NMDA antagonists such as memantine and nitroglycerin., and the combination drug nitro-memantine, are promising as drugs in treating neurodegenerative diseases.
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页码：717 / 724
页数：8
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