The Vascular Endothelium and Human Diseases

被引:1120
作者
Rajendran, Peramaiyan [1 ]
Rengarajan, Thamaraiselvan [1 ]
Thangavel, Jayakumar [2 ,3 ]
Nishigaki, Yutaka [1 ]
Sakthisekaran, Dhanapal [4 ]
Sethi, Gautam [5 ]
Nishigaki, Ikuo [1 ]
机构
[1] NPO Int Lab Biochem, Nakagawa Ku, Nagoya, Aichi 4540926, Japan
[2] Univ Illinois, Coll Med, Dept Pharmacol, Chicago, IL USA
[3] Univ Illinois, Coll Med, Ctr Lung & Vasc Biol, Chicago, IL USA
[4] Univ Madras, Dr ALM PG Inst Basic Med Sci, Dept Med Biochem, Madras 600113, Tamil Nadu, India
[5] Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117597, Singapore
关键词
Endothelium; Endothelial dysfunction; Atherosclerosis; Stroke; Cancer; PERIPHERAL ARTERIAL-DISEASE; C-REACTIVE PROTEIN; ANGIOTENSIN RECEPTOR ANTAGONIST; NITRIC-OXIDE SYNTHASE; CARDIOVASCULAR EVENTS; DEPENDENT VASODILATION; INSULIN-RESISTANCE; SKELETAL-MUSCLE; RENAL-FUNCTION; RISK-FACTORS;
D O I
10.7150/ijbs.7502
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Alterations of endothelial cells and the vasculature play a central role in the pathogenesis of a broad spectrum of the most dreadful of human diseases, as endothelial cells have the key function of participating in the maintenance of patent and functional capillaries. The endothelium is directly involved in peripheral vascular disease, stroke, heart disease, diabetes, insulin resistance, chronic kidney failure, tumor growth, metastasis, venous thrombosis, and severe viral infectious diseases. Dysfunction of the vascular endothelium is thus a hallmark of human diseases. In this review the main endothelial abnormalities found in various human diseases such as cancer, diabetes mellitus, atherosclerosis, and viral infections are addressed.
引用
收藏
页码:1057 / 1069
页数:13
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