Cancer risk in patients with Hashimoto's thyroiditis: a nationwide cohort study

被引：90

作者：

Chen, Y-K ^{[1
,2
,3
]}

Lin, C-L ^{[4
]}

Cheng, FT-F ^{[5
,6
]}

Sung, F-C ^{[4
,7
]}

Kao, C-H ^{[8
,9
,10
,11
]}

机构：

[1] Dept Nucl Med, Taipei, Taiwan

[2] PET Ctr, Taipei, Taiwan

[3] Fu Jen Catholic Univ, Sch Med, New Taipei City, Taiwan

[4] Management Off Hlth Data, Taichung, Taiwan

[5] Shin Kong Wu Ho Su Mem Hosp, Dept Surg, Taipei, Taiwan

[6] Natl Def Med Ctr, Taipei, Taiwan

[7] Dept Publ Hlth, Taichung, Taiwan

[8] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan

[9] China Med Univ Hosp, PET Ctr, Taichung, Taiwan

[10] China Med Univ, Coll Med, Grad Inst Clin Med Sci, Taichung, Taiwan

[11] China Med Univ, Coll Med, Sch Med, Taichung, Taiwan

来源：

BRITISH JOURNAL OF CANCER | 2013年 / 109卷 / 09期

关键词：

LYMPHOCYTIC THYROIDITIS; BREAST-CANCER; CELL LYMPHOMA; UP-REGULATION; CYCLOOXYGENASE-2; EXPRESSION; CARCINOMA; DISEASE; GLAND; INFLAMMATION;

D O I：

10.1038/bjc.2013.597

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: This study examined the risk of cancer in patients with Hashimoto's thyroiditis (HT). Methods: The Taiwanese National Health Insurance Research Database (NHIRD) was used to identify 1521 newly diagnosed HT patients from 1998-2010, and 6084 frequency-matched non-HT patients. The risk of developing cancer for HT patients was measured using the Cox proportional hazard model. Results: The incidence of developing cancer in the HT cohort was 5.07 per 1000 person-years, which was 1.68-fold higher than that in the comparison cohort (P<0.001). Compared with patients aged 20-34 years, patients in older age groups had a higher risk of developing cancer (35-55 years: hazard ratio (HR) = 5.96; 455 years: HR = 9.66). After adjusting for sex, age, and comorbidities, the HT cohort had HRs of 4.76 and 11.8 for developing colorectal cancer and thyroid cancer, respectively, compared with non-HT cohort. Furthermore, the HT cohort to non-HT cohort incidence rate ratio (IRR) of thyroid cancer was higher in the first 3 years (48.4, 95% confidence interval (CI) = 35.0-66.3), with an adjusted HR of 49.4 (95% CI = 6.39-382.4). Conclusion: Hashimoto's thyroiditis patients have a higher risk of thyroid cancer and colorectal cancer. The thyroid cancer prevention effort should start soon after HT is diagnosed, while being cautious of colorectal cancer increases with time.

引用

页码：2496 / 2501

页数：6

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