24S-hydroxycholesterol: Cellular effects and variations in brain diseases

被引:41
作者
Sodero, Alejandro O. [1 ,2 ]
机构
[1] Pontifical Catholic Univ Argentina UCA, Inst Biomed Res BIOMED, Av Alicia Moreau de Justo 1600,C1107AFF, Buenos Aires, DF, Argentina
[2] Consejo Nacl Invest Cient & Tecn, Natl Sci & Tech Res Council, Av Alicia Moreau de Justo 1600,C1107AFF, Buenos Aires, DF, Argentina
关键词
24S-hydroxycholesterol; Alzheimer disease; biomarkers of brain disease; brain; cholesterol; neurodegeneration; CHOLESTEROL HOMEOSTASIS; PLASMA; 24S-HYDROXYCHOLESTEROL; ALZHEIMERS-DISEASE; AMYLOID-BETA; CYTOCHROME-P450; 46A1; CHOLESTEROL-24S-HYDROXYLASE CYP46A1; OXIDATIVE STRESS; RAT-BRAIN; IN-VIVO; OXYSTEROLS;
D O I
10.1111/jnc.15228
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The adult brain exhibits a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme cytochrome P450 46A1 (CYP46A1) or 24-cholesterol hydroxylase, that transforms cholesterol into 24S-hydroxycholesterol (24S-HC). But before crossing the blood-brain barrier (BBB), this oxysterol, that is the most abundant in the brain, can act locally, affecting the functioning of neurons, astrocytes, oligodendrocytes, and vascular cells. The first part of this review addresses different aspects of 24S-HC production and elimination from the brain. The second part concentrates in the effects of 24S-HC at the cellular level, describing how this oxysterol affects cell viability, amyloid beta production, neurotransmission, and transcriptional activity. Finally, the role of 24S-HC in Alzheimer, Huntington and Parkinson diseases, multiple sclerosis and amyotrophic lateral sclerosis, as well as the possibility of using this oxysterol as predictive and/or evolution biomarker in different brain disorders is discussed.
引用
收藏
页码:899 / 918
页数:20
相关论文
共 138 条
[31]   Steady-state levels of retinal 24S-hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat [J].
Fourgeux, Cynthia ;
Martine, Lucy ;
Pasquis, Bruno ;
Maire, Marie-Annick ;
Acar, Niyazi ;
Creuzot-Garcher, Catherine ;
Bron, Alain ;
Bretillon, Lionel .
ACTA OPHTHALMOLOGICA, 2012, 90 (07) :E560-E567
[32]   Analysis of oxysterols and cholesterol in prefrontal cortex of suicides [J].
Freemantle, Erika ;
Chen, Gary Gang ;
Cruceanu, Cristiana ;
Mechawar, Naguib ;
Turecki, Gustavo .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2013, 16 (06) :1241-1249
[33]   Not Just Fat: The Structure and Function of the Lipid Droplet [J].
Fujimoto, Toyoshi ;
Parton, Robert G. .
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2011, 3 (03) :1-17
[34]   24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression [J].
Fujiyoshi, Masachika ;
Ohtsuki, Sumio ;
Hori, Satoko ;
Tachikawa, Masanori ;
Terasaki, Tetsuya .
JOURNAL OF NEUROCHEMISTRY, 2007, 100 (04) :968-978
[35]   Up-regulation of -amyloidogenesis in neuron-like human cells by both 24-and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine [J].
Gamba, Paola ;
Guglielmotto, Michela ;
Testa, Gabriella ;
Monteleone, Debora ;
Zerbinati, Chiara ;
Gargiulo, Simona ;
Biasi, Fiorella ;
Iuliano, Luigi ;
Giaccone, Giorgio ;
Mauro, Alessandro ;
Poli, Giuseppe ;
Tamagno, Elena ;
Leonarduzzi, Gabriella .
AGING CELL, 2014, 13 (03) :561-572
[36]   Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime [J].
Gamba, Paola ;
Leonarduzzi, Gabriella ;
Tamagno, Elena ;
Guglielmotto, Michela ;
Testa, Gabriella ;
Sottero, Barbara ;
Gargiulo, Simona ;
Biasi, Fiorella ;
Mauro, Alessandro ;
Vina, Jose ;
Poli, Giuseppe .
AGING CELL, 2011, 10 (03) :403-417
[37]   Cholesterol metabolism and glaucoma: Modulation of Muller cell membrane organization by 24S-hydroxycholesterol [J].
Gambert, Segolene ;
Gabrielle, Pierre-Henry ;
Masson, Elodie ;
Leger-Charnay, Elise ;
Ferrerro, Arthur ;
Vannier, Arthur ;
Gendrault, Clement ;
Lachot, Meline ;
Creuzot-Garcher, Catherine ;
Bron, Alain ;
Gregoire, Stephane ;
Leclere, Laurent ;
Martine, Lucy ;
Lucchi, Geraldine ;
Truntzer, Caroline ;
Pecqueur, Delphine ;
Bretillon, Lionel .
CHEMISTRY AND PHYSICS OF LIPIDS, 2017, 207 :179-191
[38]   Plasma oxysterol profiling in children reveals 24-hydroxycholesterol as a potential marker for Autism Spectrum Disorders [J].
Grayaa, S. ;
Zerbinati, C. ;
Messedi, M. ;
Hadjkacem, I ;
Chtourou, M. ;
Ben Touhemi, D. ;
Naifar, M. ;
Ayadi, H. ;
Ayedi, F. ;
Iuliano, L. .
BIOCHIMIE, 2018, 153 :80-85
[39]   New methods for analysis of oxysterols and related compounds by LC-MS [J].
Griffiths, William J. ;
Abdel-Khalik, Jonas ;
Crick, Peter J. ;
Yutuc, Eylan ;
Wang, Yuqin .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2016, 162 :4-26
[40]   Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma [J].
Han, Mingzhi ;
Wang, Shuai ;
Yang, Ning ;
Wang, Xu ;
Zhao, Wenbo ;
Saed, Halala Sdik ;
Daubon, Thomas ;
Huang, Bin ;
Chen, Anjing ;
Li, Gang ;
Miletic, Hrvoje ;
Thorsen, Frits ;
Bjerkvig, Rolf ;
Li, Xingang ;
Wang, Jian .
EMBO MOLECULAR MEDICINE, 2020, 12 (01)