Using human induced pluripotent stem cells to treat retinal disease

被引：54
作者：
Borooah, S. [1 ,5 ]
Phillips, M. J. [2 ]
Bilican, B. [1 ]
Wright, A. F. [3 ]
Wilmut, I. [1 ]
Chandran, S. [1 ]
Gamm, D. [2 ,4 ]
Dhillon, B. [5 ]
机构：
[1] Univ Edinburgh, Sch Clin Sci, MRC Ctr Regenerat Med, Edinburgh EH16 4UU, Midlothian, Scotland
[2] Univ Wisconsin, Sch Med & Publ Hlth, Waisman Ctr, Madison, WI 53705 USA
[3] Univ Edinburgh, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
[4] Univ Wisconsin, Sch Med & Publ Hlth, Dept Ophthalmol & Visual Sci, McPherson Eye Res Inst, Madison, WI 53705 USA
[5] Univ Edinburgh, Sch Clin Sci, Edinburgh EH16 4SB, Midlothian, Scotland
来源：
PROGRESS IN RETINAL AND EYE RESEARCH | 2013年 / 37卷
基金：
英国惠康基金;
关键词：
Retina; Pluripotent; Reprogramming; Stem cells; iPS; IN-VITRO DIFFERENTIATION; VESICLE-LIKE STRUCTURES; LONG-TERM SAFETY; HUMAN IPS CELLS; PIGMENT EPITHELIUM; DIRECTED DIFFERENTIATION; DIRECT CONVERSION; PHOTORECEPTOR PRECURSORS; HUMAN FIBROBLASTS; PROGENITOR CELLS;
D O I：
10.1016/j.preteyeres.2013.09.002
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The eye is an ideal target for exploiting the potential of human induced pluripotent stem cell (hiPSC) technology in order to understand disease pathways and explore novel therapeutic strategies for inherited retinal disease. The aim of this article is to map the pathway from state-of-the art laboratory-based discoveries to realising the translational potential of this emerging technique. We describe the relevance and routes to establishing hiPSCs in selected models of human retinal disease. Additionally, we define pathways for applying hiPSC technology in treating currently incurable, progressive and blinding retinal disease. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：163 / 181
页数：19
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